Gabapentin is approved to treat postherpetic neuralgia and epilepsy with partial-onset seizures. The large majority of gabapentin prescribing off label. may be abused for euphoria, potentiating the high from opiates, reduction alcohol cravings, a cocaine-like high, as well sedation or sleep. Individuals at highest risk abusing include those opioid abuse, mental illness, previous history prescri...

carpal tunnel syndrome (cts) is a neuropathy due to the compression of the median nerve. it is shown that gabapentin in high doses is effective in treatment of cts patients. in this study we evaluated the efficacy of low doses of gabapentin in treatment of cts patients. ninety patients with cts were randomly assigned to groups a, b and c. gabapentin was administered to group a with dose of 100 ...

OBJECTIVE The objective of this study was to compare the efficacy of gabapentin with placebo for neuropathic pain at the individual and population levels. DESIGN This study used an n-of-1 trial methodology with three double-blind, randomized, crossover comparisons of gabapentin with placebo. SETTING This study was carried out at specialist outpatient clinics at two Australian hospitals. Pat...

OBJECTIVES The purpose of this study was to evaluate the analgesic effects of perioperative gabapentin on postoperative acute and chronic pain after coronary artery bypass graft (CABG) surgery with median sternotomy and internal mammary artery harvesting. DESIGN A double-blind randomized clinical study. SETTING A single-academic hospital. PARTICIPANTS Patients with ischemic heart disease ...

BACKGROUND Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents. In a double-blind, randomized, controlled trial, we examined whether gabapentin decreases postoperative opioid consumption for pediatric spinal fusion patients with idiopathic scoliosis. METHODS Patients, aged 9 to 18 years, received preoperative gabapen...

BACKGROUND Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of clinical trials indicate that gabapentin and pregabalin could be effective as p...

BACKGROUND This study was designed to determine whether a 4 day perioperative regimen of gabapentin added to celecoxib improves in-hospital rehabilitation and physical function on postoperative day 4 and 6 weeks and 3 months after total knee arthroplasty (TKA). METHODS After Research Ethics Board approval and informed consent, 212 patients were enrolled in a randomized, double-blinded, placeb...

Chronic pelvic pain (CPP) affects 2.1-24% of women. Frequently, no underlying pathology is identified, and the pain is difficult to manage. Gabapentin is prescribed for CPP despite no robust evidence of efficacy. We performed a pilot trial in two UK centres to inform the planning of a future multicentre RCT to evaluate gabapentin in CPP management. Our primary objective was to determine levels ...

AIM To investigate the effects of genistein in a rat model of sciatic nerve crush injury and complete sciatic nerve transection. The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury. MATERIAL AND METHODS Forty-eight rats were randomly divided into six groups (8 rats in each group): group 1 (sham); group 2, sciat...

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hyd...