Cyclin G2 (CCNG2) is an atypical cyclin that functions to inhibit cell cycle progression and is often dysregulated in human cancers. We have previously shown that cyclin G2 is highly unstable and can be degraded through the ubiquitin/proteasome pathway. Furthermore, cyclin G2 contains a PEST domain, which has been suggested to act as a signal for degradation by multiple proteases. In this study...

OBJECTIVES Diabetes negatively affects the outcome of patients undergoing percutaneous transluminal coronary angioplasty (PTCA) or coronary surgery. However, data are lacking with respect to the impact of arterial revascularization in the diabetic population. METHODS Between 1999 and 2003, 100 of 491 diabetics underwent coronary artery bypass graft surgery (CABG) with total arterial grafting ...

Two phosphonium-derived ionic liquids: trihexyltetradecylphosphonium bis(2-ethylhexyl)phosphate (IL1) and tricyanomethanide (IL2) were used as additives in lithium complex- (G1) anhydrous calcium-based (G2) greases at 5 wt%. Friction torque wear tests performed using a modified four-ball machine for testing rolling bearings order to determine the friction reducing properties of these grease sam...

Let α(G) and β(G) be the independent number and vertex covering number of G, respectively. The Kronecker Product G1 ⊗ G2 of graph of G1 and G2 has vertex set V (G1 ⊗ G2) = V (G1) × V (G2) and edge set E(G1 ⊗ G2) = {(u1v1)(u2v2)|u1u2 ∈ E(G1) and v1v2 ∈ E(G2)}. In this paper, let G is a simple graph with order p, we prove that, α(Km,n⊗G)= max {(m+n)α(G),p max{m,n}} and β(Km,n⊗G) =min {(m + n)β(G)...

Let G1 and G2 be graphs on n vertices. If there are edge-disjoint copies of G1 and G2 in Kn, then we say there is a packing of G1 and G2. A conjecture of Bollob as and Eldridge [5] asserts that, if ( (G1) + 1)( (G2) + 1) n+ 1 then there is a packing of G1 and G2. We prove this conjecture when (G1) = 3, for su ciently large n.

An almost-direct product of free groups is an iterated semidirect product of finitely generated free groups in which the action of the constituent free groups on the homology of one another is trivial. We determine the structure of the cohomology ring of such a group. This is used to analyze the topological complexity of the associated Eilenberg-Mac Lane space. 1. Almost direct products of free...

PURPOSE The (131)I-tRRL small peptide probe has been identified in our previous study as a robust tumor molecular radiopharmaceutical that specifically binds to tumor-derived endothelial cells. In this study we developed a smaller structure cyclic tRRL (g2) radiolabeled with (99m)Tc as a novel and optimized peptide probe on tumor angiogenesis molecular imaging. METHODS Both tRRL (g2) and cont...

G1/S and G2/M cell cycle checkpoints maintain genomic stability in eukaryotes in response to genotoxic stress. We report here both genetic and functional evidence of a Gadd45-mediated G2/M checkpoint in human and murine cells. Increased expression of Gadd45 via microinjection of an expression vector into primary human fibroblasts arrests the cells at the G2/M boundary with a phenotype of MPM2 i...

This study was carried out at Sakha Animal Production Research Station, during the period from Oct., 2009 to Sept., 2010. Forty Rahmani ewes were divided into three treatment groups: the 1st, 2nd and 3rd treatment groups were intramuscularly injected (Day 0) with 1 mL GnRH analogue followed by an intramuscular injection with 0.7 mL PGF2α5 (G1), 6 (G2) or 7 (G3) days later. A second dose of 1 mL...