نتایج جستجو برای: g quadruplex aptamer
تعداد نتایج: 446287 فیلتر نتایج به سال:
G-quadruplexes (G4) have been found increasing potential in applications, such as molecular therapeutics, diagnostics and sensing. Both Thioflavin T (ThT) and N-Methyl mesoporphyrin IX (NMM) become fluorescent in the presence of most G4, but thrombin-binding aptamer (TBA) has been reported as the only exception of the known G4-forming oligonucleotides when ThT is used as a high-throughput assay ...
We report on the NMR-based solution structure of the 93del d(GGGGTGGGAGGAGGGT) aptamer, a potent nanomolar inhibitor of HIV-1 integrase. This guanine-rich DNA sequence adopts an unusually stable dimeric quadruplex architecture in K+ solution. Within each 16-nt monomer subunit, which contains one A.(G.G.G.G) pentad sandwiched between two G.G.G.G tetrads, all G-stretches are parallel, and all gua...
در سال های اخیر پایدار کردن ساختارهای G-quadruplex به عنوان یک هدف در درمان سرطان توجه زیادی را به خود جلب کرده است. مشتقات کوئینازولون (QD) از دسته لیگاندهایی هستند که جهت پایدار کردن این ساختارها طراحی و سنتز شده اند. درک ماهیت برهمکنش بین این لیگاندها و ساختار G-quadruplex از اهمیت بسیار بالایی برخوردار است. جهت بررسی دقیق تر اینکه چگونه این برهمکنش ها با تغییر ساختار لیگاند تحت تأثیر قرار م...
A simple and versatile colorimetric biosensor has been developed for sensitive and specific detection of a wide range of biomolecules, such as oligonucleotides and aptamer-recognized targets. Combining the signal transducer and catalyzed hairpin assembly (CHA)-based signal amplification, the target DNA binds with the hairpin DNA to form a new nucleic acid sequence and creates a toehold in the t...
Demonstration of the existence of G-quadruplex structures in telomeres of Stylonychia macronuclei and in the promoter of c-myc in human cells has validated these secondary DNA structures as potential targets for drug design. The next important issue is the selectivity of G-quadruplex-interactive agents for the different types of G-quadruplex structures. In this study, we have taken an important...
Abscisic acid (ABA) plays an important role in abiotic stress response and physiological signal transduction resisting to the adverse environment. Therefore, it is very essential for the quantitative detection of abscisic acid (ABA) due to its indispensable role in plant physiological activities. Herein, a new detection method based on localized surface plasmon resonance (LSPR) using aptamer-fu...
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