The affinity of the psychotropic benzodiazepine drugs diazepam (DZ) and flurazepam (FZ) to phosphatidylserine (PS) was examined since PS is abundantly contained in brain membranes. The effect of PS content on the partition coefficients (K(p)s) of these drugs between phosphatidylcholine (PC)-PS bilayer membranes of small unilamellar vesicles (SUV) and water was measured using second derivative s...

The purpose of the present study was to examine the influence of heat-induced superaggregation of Amphotericin B (AmB) in the Fungizone (FZ) formulation on its interaction with human serum components and relate this to reduced toxicity. Whole serum distribution studies showed that a significantly lower percentage of AmB from HFZ was recovered in the high-density lipoprotein (HDL), low-density l...

Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine. Wnt signalling has also been shown to play a role in human Mesenchymal Stem Cell (hMSC) fate, which have shown potential as a cell therapy in bone and cartilage tissue engineering...

A bstract We present a comprehensive analysis of supersymmetry anomalies in the free and massless Wess-Zumino (WZ) model perturbation theory. At classical level possesses $$ \mathcal{N} N = 1 superconformal symmetry, which is partially broken by quantum anomalies. The form part symmetry they break depend on m...

The Lycian Nappes contain slices of ophiolites and sedimentary rocks various ages that crop out in SW Turkey. They evolved were emplaced under the effect Late Cretaceous-Miocene compressional regime. Tavas Nappe is part contains Jurassic-Eocene sediments. Babadağ Formation, forming middle Nappe, composed limestone at base sized calciturbidites with chert intercalations upper part. Standard Micr...

The leading–twist wave functions of the pion and the photon at a low normalization point are calculated in the effective low–energy theory derived from the instanton vacuum. The pion wave function is found to be close to the asymptotic one, consistent with the recent CLEO measurements. The photon wave function is non-zero at the endpoints. This different behavior is a consequence of the momentu...

We construct the general Lagrangian for relativistic and heavy baryon chiral perturbation theory with virtual photons to fourth order. We work out the electromagnetic and strong isospin violating contributions to the nucleon self–energy, the nucleon mass and the scalar form factor of the nucleon. Electromagnetic effects for the shift to the Cheng–Dashen point can be as large as 2 MeV. We also d...

In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a receptor. Using a heterologous system, we show that Dsh is recruited selectively to the membrane by Fz but not DFz2, and this recruitment depends on the DEP domain but not the PDZ domain in Dsh. A m...