The genome of the predatory bacterium Herpetosiphon aurantiacus 114-95T harbors a number of biosynthesis genes, including four terpene cyclase genes. To identify the terpenes biosynthesized from H. aurantiacus 114-95T, we fed the strain with 13C-labeled glucose and, subsequently, searched for characteristic mass shifts in its metabolome. This approach led to the discovery of a new natural produ...

Diterpenoid natural products cover a vast chemical diversity and include many medicinally and industrially relevant compounds. All diterpenoids derive from a common substrate, (E,E,E)-geranylgeranyl diphosphate, which is cyclized into one of many scaffolds by a diterpene synthase (DTS). While diterpene biosynthesis has been extensively studied in plants and fungi, bacteria are now recognized fo...

Six new ent-kaurane diterpene glycosides, pharbosides A-F (1-6), and a new ent-gibbane diterpene glycoside, pharboside G (7), together with three known ent-kaurane diterpenoids, 7beta,16beta,17-trihydroxy-ent-kauran-6alpha,19-olide (8), 6beta,7beta,16alpha,17-tetrahydroxy-ent-kauranoic acid (9), and 6beta,7beta,16beta,17-tetrahydroxy-ent-kauranoic acid (10), were isolated from an ethanolic extr...

The essential oils of Salvia ovalifolia, S. procurrens and uliginosa were obtained by hydrodistillation analyzed gas chromatography-mass spectrometry. three species displayed very low amounts oils, consisting a few sesquiterpenes, aliphatic compounds such as aldehydes long-chain fatty acids. From the leaves uliginosa, an exudate was which presented diterpene icetexone major component. evaluated...