objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

Recovery of consciousness following severe brain injuries can occur over long time intervals. Importantly, evolving cognitive recovery can be strongly dissociated from motor recovery in some individuals, resulting in underestimation of cognitive capacities. Common mechanisms of cerebral dysfunction that arise at the neuronal population level may explain slow functional recoveries from severe br...

conclusions these results showed that the administration of sdf-1a increases the number of proliferating cells in the injured area in the spinal cord and improves functional recovery. results significant improvements in locomotor function were detected in the sdf-1 group compared with the sci and vehicle groups (p < 0.05). the results showed that sdf-1 treatment increased proliferative cells at...

Cranioplasty following decompressive craniectomy is reported to result in improved blood flow, cerebral metabolism, and concomitant neurological recovery. We used multimodal functional imaging technology to study a patient with marked neurological recovery after cranioplasty. Resting-state networks and auditory responses obtained with functional MRI and cerebral metabolism obtained with PET bef...

Acute myocarditis is an acute inflammatory syndrome characterized by acute myocardial damage and dysfunction followed by a variable recovery over time with some patients progressing toward severe dilated cardiomyopathy. Cardiomyocyte apoptosis, a key pathologic feature of heart failure, may play a critical role in functional recovery in patients with acute myocarditis. The aim of the study was ...

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were u...

A reorganization of cortical representations is postulated as the basis for functional recovery following many types of nervous system injury. Neuronal mechanisms underlying this form of cortical plasticity are poorly understood. The present study investigated the hypothesis that the basal forebrain cholinergic system plays an essential role in enabling the cortical reorganization required for ...