purpose: dry eye syndrome is a multifactorial disorder of the tear film and ocular surface that results in eye discomfort, visual disturbance, and often ocular surface damage. studies suggest that the prevalence of clinically diagnosed dry eye syndrome (des) is 0.4%. to 0.5%, which is highest among women and the elderly. the burden of des can be substantial, affecting visual function, daily act...

The Drosophila memory gene amnesiac is expressed in neurons that project to mushroom body axons. Blockade of synaptic transmission in the amnesiac-expressing cells disrupts memory, but not learning, suggesting presynaptic and postsynaptic sites for memory formation.

This is a book at once of Anatomy and Physiology. Chapter VIII, for instance, discusses ovarian endocrine function and its control. The section starts with a description of the hormones of the ovary wherein the relationship with anterior lobe of the pituitary gland is fully discussed. Further on ovarian activity from birth to puberty, during sexual maturity, during pregnancy and finally in the ...

frog. The wall is simply that part of the hoof that is visible when the horse is standing. It covers the front and sides of the third phalanx, or coffin bone. The wall is made up of the toe (front), quarters (sides) and heel. When the foot is lifted off the ground, the sole and frog are visible, as well as the bars of the wall and the collateral grooves (see Figure 1). The wall of the hoof is c...

MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs. To understand how Microprocessor recognizes pri-miRNAs, we here reconstitute human Microprocessor with purified recombinant proteins. We find that Microprocessor is an ∼364 kDa heterotrimeric complex of one DROSHA and two...

Basal ganglia disorders are a heterogeneous group of clinical syndromes with a common anatomic locus within the basal ganglia. To account for the variety of clinical manifestations associated with insults to various parts of the basal ganglia we propose a model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection...

The foot is constituted from a series of small bones making a segmented structure with multiple joints, likened to a dome, in contact with the ground in three points: posteriorly the calcanear tuberosity; anteriorly and medially the head of 1st metatarsum, and anteriorly and laterally the head of 5th metatarsum. In fact, each foot presents a semi-arch whose base is represented by the lateral bo...