The human placenta, a complex organ, which facilitates exchange between the fetus and the mother, contains abundant extracellular matrix (ECM) components and well-preserved endogenous growth factors. In this study, we designed a new dermal substitute from human placentas for full-thickness wound healing. Highly porous, decellularized ECM sheets were fabricated from human placentas via homogeniz...

Wound Healing As reported by Joo H. Kang and co-workers in article number 2211149, implantable vascularized engineered thrombi (IVET) using autologous blood can improve wound healing creating robust microcapillary networks. By aligning fibrin fibers activating platelets through microfluidic shear stress, the create a moderate stiffness microenvironment that promote endothelial cell maturation v...

This report describes favorable outcomes in 9 patients with skin avulsion injuries of the extremities who underwent full-thickness skin grafting and basic fibroblast growth factor (bFGF) application. Following removal of contaminated subcutaneous fat tissue on the inside of skin, the avulsed skin was processed into a full-thickness skin graft, with as much of the skin used as possible irrespect...

thickness skin graft to a large surgical wound in a patient with sclerodermatous skin. In this case history, the key point is a clinical one—that wound healing may be uncomplicated even if the graft is taken from affected sclerodermatous skin and transplanted to another affected area. There are reports in the literature of using artificial [8], split thickness [9] and autologous [10] skin graft...

Although it is well known that wound healing proceeds incredibly quickly in urodele amphibians, such as newts and salamanders, little is known about skin-wound healing, and no bioactive/effector substance that contributes to wound healing has been identified from these animals. As a step toward understanding salamander wound healing and skin regeneration, a potential wound-healing-promoting pep...

Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) ...

Skin wound closure remains a major problem in acute and reconstructive skin grafting after large burns because of limited availability of donor skin. This report evaluates six protocols for preparation in vitro of skin substitutes composed of cultured human cells, biopolymers, and growth factors for wound closure. Full-thickness wounds in athymic mice treated in a single procedure with cultured...

Infection, pain, and cosmetically unacceptable scarring frequently complicate full-thickness burns. Outpatient management can be difficult without specialized care. A retrospective case series study was conducted in a rural wound center lacking specialized burn care to assess the clinical effectiveness of acoustic pressure wound therapy, a noncontact low-frequency, nonthermal ultrasound wound t...

In I896, Krause reported the use of the same type of graft in a large series of cases and described in great detail a technique which differs little from that employed to-day. In view of this work, in which full credit was given to the earlier reports of Wolfe and others, it is not unreasonable that this graft should be named, as it frequently is, the Wolfe-Krause graft. " Full-thickness," " De...