نتایج جستجو برای: frequency response analysis fra
تعداد نتایج: 3952772 فیلتر نتایج به سال:
BACKGROUND In the Drosophila embryonic nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase. Abl binds to the cytoplasmic domain of Fra and loss-of-function mutations in abl enhance fra-dependent commissural defects. To further test Abl's role in attractive signaling, we over-expressed Abl in F...
Fos-related antigen-1 (Fra-1) is a member of the activator protein-1 transcription factor superfamily. It plays important roles in oncogenesis in various types of malignancies. Herein, we investigated the expression of Fra-1 in lung cancer tissues by qPCR, immunohistochemistry, and western blot technologies. The results showed that Fra-1 was overexpressed in the lung cancer tissues when compare...
The ligand hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase, c-Met, are highly expressed in most human malignant mesotheliomas (MMs) and may contribute to their increased growth and viability. Based upon our observation that RNA silencing of fos-related antigen 1 (Fra-1) inhibited c-met expression in rat mesotheliomas (1), we hypothesized that Fra-1 was a key playe...
In the context of Wireless Sensor Networks (WSNs), in this paper, the authors present a new agent based routing protocol named Fast Rumor Agents protocol (FRA). The FRA protocol optimizes the agent (respectively the query) propagation through the network preventing backward paths. With FRA, a rumor must have a straight trajectory, reducing the total overhead of the network. Performances compari...
Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Fra-1 (FOSL1) plays important roles in oncogenesis in various malignancies. We investigated the expression of Fra-1 in gastric cancer (GC) tissues by qPCR, immunohistochemistry (IHC) and western blot technologies. The results showed that Fra-1 was overexpressed in gastric cancer tissues compared w...
In this study, the method of multiple scales is used to perform a nonlinear vibration analysis of a mechanical system in two cases; with dry and lubricated clearance joints. In the dry contact case, the Lankarani-Nikravesh model is used to represent the contact force between the joined bodies. The surface elasticity is modeled as a nonlinear spring-damper element. Primary resonance is discussed...
The effect of frequency content on the dynamic response of concrete gravity dams is investigated in this paper. Dams are one of the most complex structures to handle when there is dynamic analysis involved. One of the influential parameters on these structureschr('39') seismic response is the frequency content of the earthquakes. An index to represent frequency content, which represents frequen...
PTH and PTH-related protein (PTHrP) are key mediators of skeletal development and homeostasis through their activation of the PTH-1 receptor. Previous studies have found that several AP-1 family members are regulated by PTH, such as c-fos, fra-1, and c-jun. There are numerous genes in the bone microenvironment that contain AP-1 sites, and different Fos family members are reported to have opposi...
Lung cancer remains the leading common cause of cancer-related death, with non-small-cell lung cancer (NSCLC) accounting for 80% of all cases. To date, platinum-based doublet chemotherapy is the cornerstone of first-line therapy. However, these agents have limited use in patients who have relapsed and have metastatic disease. Therefore, novel strategies are required to improve the clinical outc...
Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone osteocalcin (Ocn). However, it is not fully understood how many transcription factors expressed in osteoblasts regulate the endocrine function. Here, we show that mice with osteoblast-specific deletion of Fra-2 (Fosl2) have low bone mass but increased bod...
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