Hematopoietic cytokine receptor signaling pathways involve activation of signal transducers and activators of transcription (STAT) proteins, which are postulated to be involved in cellular differentiation. Aberrant STAT isoforms (/J forms rather than the normal a forms) have been described and have been found to block the normal signaling pathway from the receptor. Bcr/Abl proteins have been su...

The D(d, n)3He reaction is one of the common monoenergetic neutron sources. We compile Frag Data table from literature as an external cross-section data for PHITS. confirm validity by calculation total and angular yield calculations ideal deuterium thin target. Finally, PHITS with applied to spectrum gas target deuterium-loaded titanium Tohoku University Fast Neutron Laboratory.

Signal transducers and activators of transcription (STATs) facilitate action of cytokines, growth factors and pathogens. STAT activation is mediated by a highly conserved SH2 domain, which interacts with phosphotyrosine motifs for specific STAT-receptor contacts and STAT dimerization. The active dimers induce gene transcription in the nucleus by binding to a specific DNA-response element in the...

Belief propagation is a message-passing algorithm for performing inference in graphical models that has been implemented in a variety of domains including artificial intelligence, information theory and statistical physics. As we know, BP provides exact results only on a relatively restrictive subclass of problems, when the graphical model is a tree (or more generally if each connected componen...