BACKGROUND Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical rele...

The epigenetic regulation of transcription factor genes is critical for T-cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg-specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is required for stable expression of FOXP3 and suppressive function. We analysed the i...

Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates diverse cellular functions. It has been found that CD4(+)CD25(+) regulatory T (T(REG)) cells exert their suppressor function by transferring cAMP to responder T cells. Here, we show that miR-142-3p regulates the production of cAMP by targeting adenylyl cyclase (AC) 9 messenger RNA in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T(REG)...

BACKGROUND FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients. METHODS A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 po...

Introduction T regulatory cells (Treg), vital to prevent autoimmunity, are defined by expression of FoxP3 in combination with high CD25 and low CD127 expression. It has been reported, however, that upon in vitro activation, conventional T cells (Tconv) can manifest phenotypic marks associated with Treg and, as such, expression of these markers alone is insufficient to determine Treg commitment....

OBJECTIVE To investigate whether polymorphisms in forkhead box protein 3 (FOXP3) and EBV-induced gene 3 (EBI3) genes are associated with allergic rhinitis (AR) in Chinese patients. METHODS A population-based case-control association study design was used to assess the risk of AR conferred by single nucleotide polymorphisms (SNPs) in FOXP3 and EBI3 gene regions. DNA was extracted from 378 pati...

The transcription factor FOXP3 plays an essential role in regulatory T cell development and function. In addition, it has recently been identified as a tumor suppressor in different cancers. Here, we report that FOXP3 is expressed in normal brain but strongly down-regulated in glioblastoma (GB) and in corresponding GB stem-like cells growing in culture as neurospheres (GB-NS), as evaluated by r...

Naive CD4 T cells can differentiate into a number of functional subsets in response to Ag, including Foxp3(+) induced regulatory T cells (iTregs). The in vivo development and function of iTregs has been primarily demonstrated in systems involving Ag encountered systemically or delivered via the intestinal mucosa. In this study, we demonstrate that de novo Foxp3 expression in naive CD4 T cells i...

FOXP3 is a transcription factor that is well known to be the hallmark of immune suppressive T regulatory cells (Tregs), especially thymically derived natural Tregs. Lack of FOXP3-expressing T cells can lead to autoimmune disease, whereas an abundance of FOXP3expressing T cells can result in immune deficiency. Increased levels of FOXP3-positive Tregs in peripheral blood and tumor have been repor...

AESTKACT. This paper argues the case for the lcgalizatioii of addictive drugs such as iiiarijuaiia, cocaine, aiid licroin. It maintains that there are no “market failures” which could justify a banning of thcsc substaiiccs, and that, as in the earlier historical case of prohibition of alcohol, our present drug policy has increased crinic, decreased respect for lcgitiiriate law, and created grea...