نتایج جستجو برای: founder effect
تعداد نتایج: 1647862 فیلتر نتایج به سال:
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) has been identified in diverse countries. However, outside of North America, North Africa, and Europe, ARSACS was recognized only in the Japanese population. Moreover, through genetic research, the disease is thought to exhibit no founder effect, except in the Quebec descent. Therefore, it is possible that ARSACS might be undere...
Atkinson (Reports, 15 April 2011, p. 346) concluded that language originated in western Africa and that, due to a serial founder effect, languages repeatedly lost phonemes the farther they moved from the African point of origin. Independent examination of the published data tends to refute both these claims.
Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We present here FounderTracker, a computational method for the genome-wide detection of founder mutati...
In this paper we study some causes and consequences of founder-CEO replacements among a sample of 4,172 Danish startups created by single founders in 1999 and 2000. In contrast to the extant literature on VC-financed firms, replacements among firms in our sample are more likely among the worstand best-performing firms, and replacement is not unambiguously associated with better subsequent perfo...
Mal de Meleda is a rare form of palmoplantar keratoderma, and recently mutations in the ARS (component) B gene have been identified in families with this disease. We identified a recurrent nonsense mutation, R96X, in four families of Turkish descent. In this report, we demonstrate that these families share a common ancestral haplotype at the mal de Meleda locus, suggesting a founder effect.
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