This is an updated and slightly expanded version of a tutorial given in the Mini-Course in Model Theory, Torino, February 9-11, 2011. Some parts were previously exposed in the Model Theory Seminar of Barcelona. The main goals were to clarify the relation of forking with some versions of splitting in NIP theories and to present the known results on G-compactness, including a full proof of a theo...

OBJECTIVE To determine if the manner in which a tuning fork is activated affects its vibrational response. STUDY DESIGN Diagnostic test assessment. SETTING Hearing Center of Excellence laboratory. SUBJECTS AND METHODS A Polytec OFV-5000 scanning vibrometer was used to measure the vibrational response of 256-Hz, 512-Hz, and 1024-Hz tuning forks after activation. The tuning forks were activ...

length- weight relationship and growth pattern, condition factor and length at first maturity of yellowfin seabream were investigated in the persian gulf by monthly sampling of 30 fish from september 2011 to august 2012. maximum (31.45± 4.32) and minimum (17.80± 1.85) values of fork length and maximum (720.46 ± 292.58 gr) and minimum (134.01± 45.62) values of body weight were in january and sep...

DNA damage and other forms of replication stress can cause replication forks to stall. Replication stress response proteins stabilize and resolve stalled forks by mechanisms that include fork remodeling to facilitate repair or bypass of damaged templates. Several enzymes including SMARCAL1, HLTF, and ZRANB3 catalyze these reactions. SMARCAL1 and HLTF utilize structurally distinct accessory doma...

There are many layers of regulation governing DNA replication to ensure that genetic information is accurately transmitted from mother cell to daughter cell. While much of the control occurs at the level of origin selection and firing, less is known about how replication fork progression is controlled throughout the genome. In Drosophila polytene cells, specific regions of the genome become rep...

DNA and RNA polymerases clash along the genome as they compete for the same DNA template. Cells have evolved specialized strategies to prevent and resolve replication and transcription interference. Here, we review the topology and architecture at sites of replication fork clashes with transcription bubbles as well as the regulatory circuits that control replication fork passage across transcri...

The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated remain unclear. Here, we describe two major fork restart pathways, and demonstrate that their selection is governed by 53BP1 and BRCA1, which are known to control the pathway choi...

We present a framework to transform PRAM programs from the PRAM programming language Fork to CUDA C, so that they can be compiled and executed on a Graphics Processor (GPU). This allows to explore parallel algorithmics on a scale beyond toy problems, to which the previous, sequential PRAM simulator restricted practical use. We explain the design decisions and evaluate a prototype implementation...

Caffeine has been suggested as a chemical indicator for domestic wastewater in freshwater systems, although it is not included in water quality monitoring programs. The Third Fork Creek watershed in Durham, NC, is highly urbanized, with a history of receiving untreated wastewater from leaking and overflowing sanitary sewers. The poor water quality originating in the Third Fork Creek watershed t...

Damaged replication forks activate poly(ADP-ribose) polymerase 1 (PARP1), which catalyses poly(ADP-ribose) (PAR) formation; however, how PARP1 or poly(ADP-ribosyl)ation is involved in the S-phase checkpoint is unknown. Here we show that PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity. iPOND studies reveal th...