In general, morphological, physiological, and biochemical properties of fungal cells are drastically different among solid-state (SSC), liquid-surface (LSC), and submerged cultivation (SmC) systems. In addition to these traditional cultivation systems, a unique liquid-surface cultivation [liquid-surface immobilization (LSI)] system and interface cultivation systems [extractive liquid-surface im...

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascula...

We investigated changes in the shape of tubular ternary vesicles induced by phase separation into liquid-ordered and liquid-disordered phases. Tubular vesicles transform into two types of periodically modulated vesicles depending on the area fraction of the liquid-ordered phase. One type is a necklace of oblate subunits with two circular domains of the liquid-order phase, and the other is a per...

In vitro arterial flow bioreactor systems have been used in tissue engineering as models to investigate the response of endothelial cells to shear. However, the degree to which such models can reproduce physiological flow has not been quantified. Furthermore, previous works have assumed a Poiseuille flow profile for the calculation of wall shear stresses (WSS) experienced by the endothelial lay...

Identification based PID tuning is studied. The proposed approach consists of the identification of linear or nonlinear process model and model based control design. The identification test can be performed in both open loop and closed-loop. The so-called ASYM method is used to solve the identification problem. The method identifies a low order process model with a quantification of model error...

Slow spirometry and forced spirometry (flow volume loop) are often used to measure clinically relevant lung volumes and forced expiratory and inspiratory flows. Dynamic parameters, such as forced expiratory volumes in one second (FEV1) or forced vital capacity (FVC) and static lung volumes, such as expiratory reserve volume (ERV), inspiratory capacity (IC) and inspiratory vital capacity (IVC) c...

We consider a control problem for a single bioreaction occuring in a continuous and well mixed bioreactor, assuming that the bioreaction’s kinetics is not represented by a validated model. We develop a nonlinear controller and prove the global asymptotic stability of the closed loop system towards the equilibrium corresponding to the set point. Since this control law needs the knowledge of some...