OBJECTIVE To determine the incidence of foot ulceration and lower limb amputation in type 2 diabetic patients in primary health care. RESEARCH DESIGN AND METHODS Data on type 2 diabetes were collected by the Nijmegen Monitoring Project between 1993 and 1998 as part of a study of chronic diseases. The records of all patients recorded as having diabetic foot problems and those who died, moved t...

Musculoskeletal conditions of the foot and ankle are an important public health challenge due to their increasing incidence combined with their substantial negative impact on patients' quality of life. Non-pharmacological treatments serve as the first line of treatment and are frequently used for patients with musculoskeletal conditions of the foot and ankle. This review provides a summary of t...

Abstract Motor disorders are diseases affecting the muscle function of human body. A frequently occurring motor disorder affects lower leg muscles resulting in a pathological gait called foot drop. Patients have higher risk stumbling and falling. The most common treatment is use passive ankle-foot-orthosis (AFO). However, compensation drop only limited due to non possible support all rotational...

OBJECTIVE To identify the risk factors of diabetic foot (DF) in diabetic patients. METHODS In a case-control study, medical records of 50 patients with DF, and 50 diabetic controls without DF were selected randomly from the patients seen at King Abdulaziz Medical City (KAMC), Riyadh, Kingdom of Saudi Arabia. Selected vascular, neuropathic, metabolic, health care, and lifestyle risk factors we...

BACKGROUND Podocyte foot process effacement accompanied by actin cytoskeleton rearrangements is a cardinal feature of many progressive human proteinuric diseases. RESULTS By microarray profiling of mouse glomerulus, SCHIP1 emerged as one of the most highly enriched transcripts. We detected Schip1 protein in the kidney glomerulus, specifically in podocytes foot processes. Functionally, Schip1 ...

ADF/cofilins are the major regulators of actin dynamics in mammalian cells. The activation of ADF/cofilins is controlled by a variety of regulatory mechanisms. Dysregulation of ADF/cofilin may result in loss of a precisely organized actin cytoskeletal architecture and can reduce podocyte migration and motility. Recent studies suggest that cofilin-1 can be regulated through several extracellular...

Background Information describing variation in health outcomes for individuals with diabetes related foot disease (DRFD), across socioeconomic strata is lacking. Focussing on the clinical aspects of foot disease, in individuals with DRFD that reside in areas of known social disadvantage, may not result in the desired clinical outcomes. The aim of this study was to investigate variation in rates...

Powered ankle-foot orthosis can not only prevent foot-drop and assist patients’ walking but also improve the ankle joint movement for patients with dysfunction caused by the various injuries and nervous system diseases. Common ankle rehabilitation devices limit the ankle injury patients’ rehabilitation training within fixed places, so a portable powered ankle-foot orthosis is presented in this ...

According to the American Diabetes Association, approximately 82 000 nontraumatic lower-limb amputations were performed among people with diabetes in the United States in 2002. Guidelines on managing the patient with diabetes with suspected or evident foot infection, prepared by members of the Infectious Diseases Society of America, were published recently. This article reviews the information ...