Follikülogenez mekanizması çeşitli hormonları, büyüme faktörlerini ve sinyal moleküllerini içeren karmaşık bir süreçtir. Foliküler gelişim mekanizmaları üzerine gelecekteki araştırmalar, dişi reprodüktif yaşamı hakkında daha kapsamlı veriler sağlayacaktır. Vitamin D, steroidogenez yoluyla follikülogenezi etkiler. Granüloza hücrelerinde D reseptör sinyali hormon salgılarını steroidojenik enzimle...

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Background: Understanding ovarian folliculogenesis is critical to the study of fertility and in the development of fertility techniques as well as contraception. Mares and women share striking similarities in ovarian folliculogenesis, and in insulin resistance and obesity syndromes. The effects of insulin resistance and obesity on follicular development and the surrounding endocrinology and gen...

Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundant not only in the brain, but also in the testis. Immunohistochemical studies have shown that PACAP-LI in rat testis is expressed stage specifically in spermatids. This suggests that testicular PACAP participates in the regulatory mechanism of spermatogenesis. Additionally, the ovary contains a relatively small amount of PACAP,...