نتایج جستجو برای: fmos interaction

تعداد نتایج: 565752  

2016
Nasir Rasool Aqsa Kanwal Tehmina Rasheed Quratulain Ain Tariq Mahmood Khurshid Ayub Muhammad Zubair Khalid Mohammed Khan Muhammad Nadeem Arshad Abdullah M. Asiri Muhammad Zia-Ul-Haq Hawa Z. E. Jaafar

Synthesis of 2,5-bisarylthiophenes was accomplished by sequential Suzuki cross coupling reaction of 2-bromo-5-chloro thiophenes. Density functional theory (DFT) studies were carried out at the B3LYP/6-31G(d, p) level of theory to compare the geometric parameters of 2,5-bisarylthiophenes with those from X-ray diffraction results. The synthesized compounds are screened for in vitro bacteria scave...

2008
F. B. Abdalla A. Mateus W. A. Santos L. Sodré I. Ferreras O. Lahav

We explore the prospects of predicting emission line features present in galaxy spectra given broad-band photometry alone. There is a general consent that colours, and spectral features, most notably the 4000 Å break, can predict many properties of galaxies, including star formation rates and hence they could infer some of the line properties. We argue that these techniques have great prospects...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Rachel M Novick Ann M Mitzey Mark S Brownfield Adnan A Elfarra

Flavin-containing monooxygenases (FMOs) play significant roles in the metabolism of drugs and endogenous or foreign compounds. In this study, the regional distribution of FMO isoforms 1, 3, and 4 was investigated in male Sprague-Dawley rat liver and kidney using immunohistochemistry (IHC). Rabbit polyclonal antibodies to rat FMO1 and FMO4, developed using anti-peptide technology, and commercial...

2018
Dalia Ali Sarah Abuelreich Nora Alkeraishan Najla Bin Shwish Rimi Hamam Moustapha Kassem Musaad Alfayez Abdullah Aldahmash Nehad M. Alajez

Bone marrow adipocyte formation plays a role in bone homeostasis and whole body energy metabolism. However, the transcriptional landscape and signaling pathways associated with adipocyte lineage commitment and maturation are not fully delineated. Thus, we performed global gene expression profiling during adipocyte differentiation of human bone marrow stromal (mesenchymal) stem cells (hMSCs) and...

Journal: :Turkish Journal of Chemistry 2022

Synthesis of a new fluorinated nucleoside 6,7-difluoro-2-methyl-4-quinazolinone was described. 2-Amino-4,5-difluorobenzoic acid 1 reacts with (CH3CO)2O followed by ammonia to form (1H)-6,7-difluoro-2-methyl-4-quinazolinone 3a. Ribosylation silylated 4 l-O-acety1-2,3-5-tri-O-benzoyl-α-D-ribofuranose 5 forms protected 6 then unprotected from give free 7. Greener pasture biological docking the cys...

Journal: :Molecules 2015
Mnaza Noreen Nasir Rasool Yasmeen Gull Muhammad Zubair Tariq Mahmood Khurshid Ayub Faiz-Ul-Hassan Nasim Asma Yaqoob Muhammad Zia-Ul-Haq Vincenzo de Feo

A variety of novel 5-aryl thiophenes 4a-g containing sulphonylacetamide (sulfacetamide) groups were synthesized in appreciable yields via Pd[0] Suzuki cross coupling reactions. The structures of these newly synthesized compounds were determined using spectral data and elemental analysis. Density functional theory (DFT) studies were performed using the B3LYP/6-31G (d, p) basis set to gain insigh...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Piyush M Vyas Sanjoy Roychowdhury Sevasti B Koukouritaki Ronald N Hines Sharon K Krueger David E Williams William M Nauseef Craig K Svensson

Arylamine compounds, such as sulfamethoxazole (SMX) and dapsone (DDS), are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that auto-oxidize to arylnitroso derivatives, which in turn bind to cellular proteins and can act as antigens/immunogens. Previous studies have demonstrated that neither cytochromes P450 nor cyclooxygenases mediate this bioactivation in normal human ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2007
J E Ballard T Prueksaritanont C Tang

MK-0457 (N-[4([4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5 -yl)amino]pyrimidin-2-yl]thio)phenyl]cyclopropanecarboxamide), an Aurora kinase inhibitor in development for the treatment of cancer, was evaluated for its in vitro metabolism in different species. This compound primarily underwent N-oxidation and N-demethylation in human, monkey, dog, and rat liver preparations. However, N-dem...

Journal: :The Journal of clinical endocrinology and metabolism 1997
M M Miller R A James J K Richer D F Gordon W M Wood K B Horwitz

Progesterone is a key developmental, proliferative, and differentiative hormone in the breast and endometrium, and it can accelerate carcinogenesis in the mammary gland epithelium. In the breast and uterus, progesterone acts through two coexpressed isoforms of progesterone receptors, the B- and A-receptors. To study the function of each isoform in isolation, we previously constructed two breast...

2006
Luis Oliva Masahiro Yamao

Japan is considered as one of the most successful marine fishery co-management or CBFM regimes. However, in 2001 the Japanese government was obliged to introduce new measures in order to recover several species under overexploitation. One example is the Resource Recovery Plans (RRP) that in all Japan accounts 51 fisheries. This paper attempts to clarify the level of sustainability of coastal fi...

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