We describe an efficient method for generating female germline mosaics by inducing site-specific homologous mitotic recombination with a yeast recombinase (FLP) which is driven by a heat shock promoter. These germline mosaics are produced in flies heterozygous for the agametic, germline-dependent, dominant female sterile (DFS) mutation ovoD1, where only flies possessing germline clones are able...

The Front Cover shows a drawing of the Rocky Mountains in Alberta, Canada. new frustrated Lewis pair (FLP) [iPr2P(C13H8)BCy2] is depicted at center drawing. This molecule contains an unusually reactive B−C bond which behaves as “masked” FLP. molecules to its left and right depict FLP's reaction products with Cl2PPh H3N•BH3, respectively; these demonstrate ability activate P−Cl N−H bonds. raccoo...

The ability of site-specific recombinases, like FLP and Cre, to catalyze alterations in genomic DNA is well established, whereas their application to genetic engineering strategies has been restricted because of the inability to temporally regulate their expression and subsequent recombination events in specific populations of cells. We describe a regulatory system for ecdysone-controlled expre...

Herein we report the metal-free diastereoselective frustrated Lewis pair (FLP)-catalyzed hydrogenation of azaMorita−Baylis−Hillman (aza-MBH) adducts, accessing a diverse range of stereodefined β-amino acid derivatives in excellent isolated yields (28 examples, 89% average yield, up to 90:10 d.r.). Furthermore, sequential organo-FLP catalysis has been developed. An initial organocatalyzed aza-MB...

In this paper, we introduce a class of fuzzy linear programming problems and de ne the concepts of feasible and satis cing solutions—the necessary tools for dealing with such problems. In this way, we show that the class of crisp (classical) LP problems can be embedded into the class of FLP ones. Moreover, for FLP problems we de ne the concept of duality and prove the weak and strong duality th...

The facility location problem (FLP) is a complex optimization that has been widely researched and applied in industry. In this research, we proposed two innovative approaches to complement the limitations of traditional methods, such as heuristics, metaheuristics, genetic algorithms. first approach involves utilizing crowdsourcing through video game players obtain improved solutions, filling ga...

Frustrated Lewis pair (FLP) chemistry enables a rare example of alkyne 1,2-hydrocarbation with N-methylacridinium salts as the carbon Lewis acid. This 1,2-hydrocarbation process does not proceed through a concerted mechanism as in alkyne syn-hydroboration, or through an intramolecular 1,3-hydride migration as operates in the only other reported alkyne 1,2-hydrocarbation reaction. Instead, in th...

Return migration has probably been granted the lowest attention in field of family language policy (FLP). The current paper seeks to address this gap research and explores dynamics FLP a Polish context their temporary Germany return Poland. authors investigate how mobility affects FLP, especially towards L1 (Polish) L2 (German) migration. study takes qualitative, interview-based design, support...

The family limited partnership (“FLP”) has ascended to the summit of favored estate planning techniques in the past decade or so.1 For years, the FLP appeared to be almost invincible, although the Internal Revenue Service (“Service”) volleyed numerous attacks at the FLP, only to be repeatedly defeated by the courts—that is, until recently. In several recent cases, the Service has successfully f...