Introduction: The goal of the current study was to create and assess herbal floating tablet that would treat stomach ulcers. Many medications are currently on market have either been directly or indirectly produced from plants, which long considered an experimental source medication. Different diseases treated with plant extracts. There so many chemically active components in plants can be used...

Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

The present study was aimed at the development of gastroretentive floating pulsatile release tablets (FPRTs) of lercanidipine HCl to enhance the bioavailability and treat early morning surge in blood pressure. Immediate release core tablets containing lercanidipine HCl were prepared and optimized core tablets were compression-coated using buoyant layer containing polyethylene oxide (PEO) WSR co...

Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy. The purpose of this study was to optimize and evaluate floating tablets of hydralazine hydrochloride designed to prolong the gastric residence time and to pro...

The purpose of this research was to prepare and evaluate floating drug delivery system of Lamivudine. Floating matrix tablets of Lamivudine were developed to prolong gastric residence time and increase its bioavailability. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administe...

Nifedipin merupakan salah satu obat yang sering digunakan dalam pengobatan hipertensi dengan frekuensi penggunaan berulang kali sehari, karena itu nifedipin perlu diformulasikan bentuk sediaan lepas lambat. Banyak metode dapat untuk membuat lambat, satunya adalah dirancang tetap tinggal di lambung. Penelitian ini bertujuan mengetahui pengaruh konsentrasi natrium bikarbonat sebagai komponen effe...