Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic level within solid tumors as well as on the macroscopic level across metastases may also contribute to acquired drug resistance. Here we use m...

Different aspects of sociality bear considerable weight on the individual- and group-level welfare of captive nonhuman primates. Social Network Analysis (SNA) is a useful tool for gaining a holistic understanding of the dynamic social relationships of captive primate groups. Gaining a greater understanding of captive chimpanzees through investigations of centrality, preferred and avoided relati...

Many countries especially developing ones like Ghana see tourism as a conduit for socio-economic development. This paper aims to examine stakeholders’ perceptions of the effect Buabeng-Fiema Monkey Sanctuary. To achieve this aim, research was carried out into role (a Sanctuary) in promoting rural development Ghana. The systematic sampling and purposive methods were used select 265 household hea...

OBJECTIVE Recent studies show a high prevalence of trauma symptoms among people with serious mental illness who are treated in public-sector mental health systems. Unfortunately, growing evidence suggests that many consumers have had traumatic or harmful experiences while being treated in various psychiatric settings. This study explores consumers' perceptions of such harmful inpatient experien...

This paper aims to use the digital recording techniques and 3DCG for the ancient monument. The author applied to use these techniques in the archaeological site of the Asklepieion, Messene. The ancient Messene was an important Hellenistic city in Mainland Greece and was well known by the description of the Roman traveller, Pausanias. The Asklepieion was located in the city centre and was the ma...

We evaluate a sanctuary chimpanzee sample (N = 11) using two adapted human assessment instruments: the Five-Factor Model (FFM) and Eysenck's Psychoticism-Extraversion-Neuroticism (PEN) model. The former has been widely used in studies of animal personality, whereas the latter has never been used to assess chimpanzees. We asked familiar keepers and scientists (N = 28) to rate 38 (FFM) and 12 (PE...

We reconstructed the history of Chatthin Wildlife Sanctuary (CWS) to understand how social and economic events, and policy changes affected the sanctuary's condition. We surveyed 25 villages surrounding CWS to evaluate past and present ecological conditions, compare the results with historical accounts and identify causal relationships. During the first half of the 20th century, the primary thr...

Aerial line transect surveys, totalling 16 590 km, were performed in winter and summer 2009 in the Pelagos Sanctuary, NW Mediterranean. A total of 207 loggerhead sea turtles were sighted, with only 9 sightings during the winter. In this season average raw ‘surface’ density (i.e. animals at or near the surface) was 0.002 turtles km–2, and on the basis of line-transect analysis, we estimated 237 ...