Wnt/Frizzled signaling is involved in many developmental processes but is mostly silent in healthy adult organs. However, a reactivation of this signaling pathway is generally observed during pathological conditions, which makes it a promising therapeutic target. The recently presented crystal structure of Xenopus Wnt8 in complex with the cysteine rich domain (CRD) of Frizzled8 demonstrates tha...

Giant cell tumor of tendon sheath is one the most common hand in age group 3dr -5th decades life. It index finger followed by middle ring and little finger. Here we present a report case GCTTS 15 years old boy who presented out-patient department with solitary nodule his right thumb histologically diagnosed as after total excision.

Mechanical and neurological couplings exist between musculotendon units of the human hand and digits. Studies have begun to understand how these muscles interact when accomplishing everyday tasks, but there are still unanswered questions regarding the control limitations of individual muscles. Using intramuscular electromyographic (EMG) electrodes, this study examined subjects' ability to indiv...

  Background: To evaluate safety and efficacy of percutaneous release of trigger finger in multiple digits involvement in comparison with  single digit involvement.   Method: A number of 100 patients (131 fingers) were treated by percutaneous release and divided into two groups: single digit (group A) and multiple digits (group B). They were followed up for one year. Success rate, pain, complic...

A nonpunitive fixed appliance utilizing a Teflon (E.I. du Pont de Nemours and Co., Inc., Wilmington, DE) roller is described. The appliance is used in conjunction with a program of positive reinforcement in managing thumb sucking in children 7-13 years of age. It has been used successfully in 24 children, with no cases requiring reinsertion.

Klippel-Trenaunay-Weber syndrome is characterized by limb hypertrophy, varicose veins, and vascular nevus. The orofacial manifestations include early eruption of permanent teeth and hemifacial hypertrophy. This 5-year-old male patient had facial asymmetry, limb abnormalities, and a thumb-sucking habit. Cephalometric analysis revealed a Class II open bite occlusion. (Pediatr Dent 16:231-35, 1994)

PURPOSE To verify the efficacy of recreational strategies of awareness for spontaneous removal of finger sucking or pacifier habits in children. METHODS Fifteen children (nine female and six male), with ages ranging from 4 to 8 years (mean age of 5.6 years) participated in the study. Recreational strategies were developed for the removal of oral habits. The program consisted of ten one-hour w...

The human opposable thumb enables the hand to perform dexterous manipulation of objects, which requires well-coordinated digit force vectors. This study investigated the directional coordination of force vectors generated by the thumb and index finger during precision pinch. Fourteen right-handed, healthy subjects were instructed to exert pinch force on an externally stabilized apparatus with t...

We investigated finger strength and the ability to control digit force/torque production in children with developmental coordination disorder (DCD) using manipulative tasks with different kinetic redundancies (KNR). Age-related changes in finger strength and finger force/torque control in typically developing (TD) children were also examined to provide a developmental landscape that allows a co...