A systematic investigation of the fibrinolytic system during the period after acute myocardial infarction in 42 patients showed a progressive reduction of fibrinolytic activity, with the longest lysis times on days 4 to 5 after the event. There is a concomitant rise in the levels of fibrinogen, plasminogen, and antiplasmin; only the latter parallels the delay in lysis. After 12 to 15 months, no...

By A. E. D R AND D. Ku ui A GROWING INTEREST in fibrinolytic agents has given rise to a variety of methods for assessing the activity of such agents in vitro. The fibrin plate assay1 is a useful technic employing the natural substrate. Other methods,2 using formed fibrin clots, have also been devised, as well as technics employing other substrates such as casein. The purpose of this study was t...

This study was to isolate, screen, and identify microorganisms from fermented food Red Oncom and Tempeh Gembus that can produce fibrinolytic proteases. Forthy-three isolates showed proteolytic activities on skim milk agar, while thirthy-eight of them showed fibrinolytic activities both on a fibrin plate and a fibrinogen zymography. The isolates that showed activity in fibrin plate and fibrinoge...

Parameters of fibrinolysis, including euglobulin fibrinolytic activity, tissue-type plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PA-inhibitor) activity, and plasmin-alpha 2-antiplasmin complex (PAP) were studied in 62 patients (35 women and 27 men; ages 53 +/- 16 years) with either insulin-dependent (IDDM) or noninsulin-dependent (NIDDM) diabetes mellitus. Compared to ...

Rice chaff (Variety: Devamallige) is used as the substrate for the production of fibrinolytic enzyme by Penicilliumchrysogenum AGSF16 in solid state fermentation. The optimized moisture content of the medium is 35-45 %( v/w) an inoculumof 5-10% (v/v) and an average particle size of 400μm of the substrate were optimum for productivity and enzyme activity of 65-70 IU per ml filtrate was achieved ...

Diurnal patterns of plasma euglobulin fibrinolytic activity, estimated by the fibrin plate method, were determined in groups of young normal and older normal subjects, in subjects with type IV hyperlipoproteinemia, and in subjects with coronary artery disease who had normal lipid profiles. The marked diumal increases in fibrinolytic activity observed in the young normal subjects were significan...

Aqueous extracts of Mucuna pruriens seeds were tested for their activity on various pharmacological effects like lethality, phospholipase activity, edema forming activity, fibrinolytic activity and haemorrhagic activity of of cobra and krait venoms. The aqueous extract displayed a significant inhibitory effect on the lethality, phospholipase activity, edema forming activity, fibrinolytic activi...

Palm wine, known as tuak in Indonesia, is a traditional alcoholic beverage in Tapanuli region, North Sumatera that is made by fermenting the sugary sap of sugar palm tree (Arenga pinnata) and the bark of tree called raru (Vatica pauciflora Blume). In this study, we screened 4 bacterial strains from palm wine, and found that T2 strain showed potential fibrinolytic activity. Several steps of puri...

A study of fibrinolytic activity in sickle-cell patients during asymptomatic periods has shown a normal fibrinolytic response to exercise and local heat to the arm. During vasoocclusive crises there was no significant decrease in fibrinolytic activity. These results contrast with earlier reports of decreased fibrinolysis during crisis and a suggestion that fibrinolytic activators might be of va...