Human plasma contains a proteolytic enzyme precursor termed plasminogen (I) or profibrinolysin (2), which, upon activation by physical agents or specific bacterial kinases, is converted to plasmin (1) or fibrinolysin (2). Streptokinase (henceforth referred to as SK), an extracellular hemolytic streptococcal product, has been a commonly used activator for human plasminogen. Two mechanisms have b...

The relation of intravascular fibrin to the leucocytic sticking reaction in ear chambers of rabbits injured by heat was investigated in two ways. First, attempts were made to destroy the thin layer of fibrin believed to coat the surfaces of cells involved in the sticking reaction. Second, white cell sticking was studied after fibrinogen had been removed from the blood stream. The results of the...

A total of 5 Staphylococcus aureus strains from patients with postinfluenzal staphylococcal pneumonia, 7 from burn patients with staphylococcal pneumonia, and 21 from the nasopharynx of carriers were phenotypically characterized. All or most strains produced coagulase, clumping factor, DNase, thermostable DNase, protease, gelatinase, lipase, and pigment; the strains were low to moderate produce...

1. The classification of fusobacteria into types, as suggested by Slanetz and Rettger on the basis of their cultural and biochemical characteristics, was confirmed. The following additional data are presented: the behavior of types I, II, and III in several previously untested carbohydrates; the final pH in 1 per cent glucose broth; the hydrolysis of starch; the failure to decompose sodium hipp...

Tumor emboli were produced in lungs of Sprague-Dawley rats by i.v. injection of Walker 256 tumor cells into the tail vein. Tissues were examined by electron microscopy at periods from 30 sec to 72 hr after tumor injection. Two methods of conventional staining were used, in addition to immunoperoxidase techniques, with antifibrin antibodies produced in rabbits. Tumor cells accompanied by a plate...

1. World Health Organization. Fact Sheet N104. Tuberculosis. March 2004. (Accessed October 1, 2004, at http://www.who.int/ mediacentre/factsheets/fs104/en.) 2. Idem . Global tuberculosis control: Vietnam. WHO report 2004. (Accessed October 1, 2004, at http://www.who.int/tb/publications/ global_report/2004/en/VietNam.pdf.) 3. Rich AR, McCordock HA. The pathogenesis of tuberculous meningitis. Bul...

Thrombokinase of the blood, while resembling enterokinase in its role of activator, is more closely analogous to trypsin in its intrinsic origin. It probably arises from a plasma precursor; but it is different from plasmin (fibrinolysin). Like trypsin, thrombokinase can activate prothrombin without the aid of other factors; however, it is potentiated by platelets plus calcium. Unlike certain ti...

I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...

a causal relationship between oral contraceptive drugs and thrombotic disease (Chicago Conference, 1962; Mills, 1964). Laboratory investigations into the possible changes in the coagulation balance which might significantly add to the risk of thrombosis have yielded conflicting results. Phillips et al. (1961) studied the effects of exogenous steroids on the clotting mechanism of human subjects....

I N PREVIOUS REPORTS1-3 various methods, including radiotracer studies, revealed the capacity of plasmin to adsorb selectively to preformed venous and arterial clots. Components of the fibrinolysin system were labeled with iodine131 and their distribution studied following intravenous administration. The highest degree of adsorption to fibrin clots was exhibited by human plasminogen activated w...