Discrimination between the physiological cleavage fragments of fibrinogen and fibrin offers an approach to differentiation between fibrinogenolytic processes and fibrinolysis after coagulation. By use of the cleavage-associated neoantigen of fibrinogen (fg-D(neo)) as a molecular marker, characteristic differences between the D regions of fibrinogen derivatives and fibrin derivatives can be demo...

Population One hundred and forty-nine postmenopausal women without previous venous thromboembolic disease. Methods Prothrombin fragment 1þ2 (F1þ2), fibrin degradation products, antithrombin, protein C, total protein S and activated protein C-normalised ratio were measured at baseline and after 6 and 12 months of HRT in six groups of healthy postmenopausal women: (A) no HRT (reference group), (B...

We demonstrate that a biphenyl-bridged imidazole dimer exhibits fast photochromism with a thermal recovery time constant of ∼100 ns, which is the fastest thermal back reaction in all reported imidazole dimers. Sub-ps transient absorption spectroscopy reveals that the generation process of the colored species occurs within 1 ps.

Density functional calculations have been employed to rationalize why the heteronuclear N(2)-bridged Mo(III)Nb(III) dimer, [Ar((t)Bu)N](3)Mo(mu-N(2))Nb[N((i)Pr)Ar](3)(Ar = 3,5-C(6)H(3)Me(2)), does not undergo cleavage of the dinitrogen bridge in contrast to the analogous Mo(III)Mo(III) complex which, although having a less activated N-N bond, undergoes spontaneous dinitrogen cleavage at room te...

Purified fibrinogen at concentrations of 3-30 nM has been found to stimulate continuous growth of human lymphoid and myeloid cell lines under serum-free conditions. A strong proliferative response resulted from the synergism elicited by the addition of fibrinogen to transferrin-supplemented medium. This effect was observed with the pre-B-cell line Raji, the T lymphoma-derived JM, and the monocy...

Advanced atherosclerosis is often associated with dystrophic calcification, which may contribute to plaque rupture and thrombosis. In this work, the localization and association of the noncollagenous bone matrix proteins osteonectin, osteopontin, and osteocalcin with calcification, lipoproteins, thrombus/hemorrhage (T/H), and matrix metalloproteinases (MMPs) in human carotid arteries from endar...

Recognition of the central role of thrombosis in the pathogenesis of cardiovascular disease has prompted growing interest in the association of haemostatic variables with cardiovascular disease. In investigating the predictive value of haemostasis markers, a promising type of measurement is that of the activation products of coagulation and fibrinolysis: prothrombin fragment 1+2 (F1+2), fibrino...

The isolation and characterization of carp (Cyprinus carpio) plasma fibrinogen and its plasmin degradation products are described. Alike other vertebrate species, carp fibrinogen is a dimeric protein and consists of three different pairs of disulfide-bonded polypeptide chains. Aa, B/f, and y. In contrast to mammalian fibrinogen, the B0 chain of carp fibrinogen has apparently a higher molecular ...