Rat papillary muscles were used to study the influence of glucose (5 HIM), linoleate (1 to 1.75 mMJ, octanoate (0.5 to 1.75 HIM) and pent-4-enoic acid (1 to 5 DIM) on mechanical performance under oxygenated, hypoxic and anoxic conditions. The buffer solution contained 0.3 DIM albumin. Free fatty acids (FFA) (1.0 to 1.75 DIM) did not alter mechanical performance under oxygenated conditions. Duri...

Livers from normal, fed male and female rats were perfused with different amounts of [1-14C]oleate under steady state conditions, and the rates of uptake and utilization of free fatty acid (FFA) were measured. The uptake of FFA by livers from either male or female rats was proportional to the concentration of FFA in the medium. The rate of uptake of FFA, per g of liver, by livers from female ra...

The fusiform face area (FFA) is a well-studied human brain region that shows strong activation for faces. In functional MRI studies, FFA is often assumed to be a homogeneous collection of voxels with similar visual tuning. To test this assumption, we used natural movies and a quantitative voxelwise modeling and decoding framework to estimate category tuning profiles for individual voxels within...

Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia with characteristic clinical pattern of progressive frontotemporal hairline recession, perifollicular erythema and hyperkeratosis and symptoms of itch and burning, occurring mainly in post-menopausal women. FFA is considered a subtype of lichen planopilaris (LPP), based on their identical histopathology. Currently, n...

The effect and time course of free fatty acid (FFA) elevation on insulin-mediated vasodilation (IMV) and the relationship of FFA elevation to changes in insulin-mediated glucose uptake was studied. Two groups of lean insulin-sensitive subjects underwent euglycemic-hyperinsulinemic (40 mU x m(-2) x min(-1)) clamp studies with and without superimposed FFA elevation on 2 occasions approximately 4 ...

We have recently shown that insulin-resistant obese subjects exhibit impaired endothelial function. Here, we test the hypothesis that elevation of circulating FFA to levels seen in insulin-resistant subjects can impair endothelial function. We studied leg blood flow responses to graded intrafemoral artery infusions of the endothelium-dependent vasodilator methacholine chloride (Mch) or the endo...

Effects of flufenamic acid (FFA) and niflumic acid (NFA), which are often used to block Ca2+-activated Clcurrent, have been investigated in voltage-clamped Xenopus oocytes expressing 01392 and a364 nicotinic ACh receptors (nAChRs). NFA and FFA inhibit a362 nAChR-mediated inward currents and potentiate ~364 nAChR-mediated inward currents in normal, Cl--free and Ca*+-free solutions to a similar e...

Animal models have demonstrated that CD36 facilitates cell membrane free fatty acid (FFA) transport, but its role in human metabolism is not well understood. We measured heart, liver, adipose (three depots), and muscle (truncal postural and thigh locomotive) FFA uptake using [(11)C]palmitate positron emission tomography (PET) scans in a family of five carrying the Pro90Ser CD36 mutation (2 homo...

BACKGROUND This study aimed to investigate whether exogenous hydrogen sulfide (H2S) can protect the RAW264.7 macrophages against the inflammation induced by free fatty acids (FFA) by blunting NLRP3 inflammasome activation via a specific TLR4/NF-κB pathway. METHODS RAW264.7 macrophages were exposed to increasing concentrations of FFA for up to 3 days to induce FFA-induced inflammation. The cel...

SCHIMMEL, RICHARD J., AND H. MAURICE GOODMAN. &Z'$~UX of free fatty acids from adipose tissue. Am. J. Physiol. 221(l) : 118-122. 197 1 .-Segments of rat epididymal adipose tissue were preincubated in Krebs-Ringer bicarbonate buffer for 30 min in the presence of epinephrine. The release of free fatty acids (FFA) formed during the preincubation period into albumin-containing media was measured du...