During the past 40 years, combined oral contraceptives (COCs) have become a key component of modern fertility regulation programmes. Today, an estimated 100 million women throughout the world use this method of contraception. With such wide-spread usage, it is perhaps not surprising that COCs have been the subject of extensive medical research.

Estrogens influence fertility and infertility in animals. This chapter reviews the use of estrogen as a contraceptive through the regulation of its production and action. It is concluded that the use of specific agonists and antagonists of estrogen action that avoid the global and unwanted side effects of estrogen offers new potential methods of contraception.

As has been the case with other types of medical tourism, the phenomenon of cross border fertility care ("CBFC") has sparked concern about the lack of global or even national harmonization in the regulation of the fertility industry. The diversity of laws around the globe leads would-be parents to forum shop for a welcoming place to make babies. Focusing specifically on the phenomenon of travel...

In the last 20 years, a pituitary-hypothalamus tissue culture system with intact neural and portal connections has been developed in our lab and used to understand the feedback mechanisms that regulate the secretions of adenohypophyseal hormones and fertility of male rats. In the last decade, several in vivo rat models have also been developed in our lab with a view to substantiate the in vitro...

Ethnobotanical investigations by various workers including the senior author during the present decade have revealed fifteen antifertility drugs employed by different tribes of Rajasthan. Ten have been reported from the southern region alone. The lower plants are represented by a single fern Actiniopteres radiate. Most drugs comprise single species and are orally administered. While some drugs ...

In the male germline of Drosophila the transformer-2 protein is required for differential splicing of pre-mRNAs from the exuperantia and att genes and autoregulates alternative splicing of its own pre-mRNA. Autoregulation of TRA-2 splicing results in production of two mRNAs that differ by the splicing/retention of the M1 intron and encode functionally distinct protein isoforms. Splicing of the ...

OBJECTIVE To identify reproductive intentions and fertility regulation practices, including contraception and abortion, in a group of high schooling adolescents and young adults. METHODS The data were gathered from a large quali-quantitative study carried out among University of São Paulo undergraduate students aged up to 24 years. The study sample consisted of 952 students who attended the u...

Interactions between bone and the reproductive system have until now been thought to be limited to the regulation of bone remodeling by the gonads. We now show that, in males, bone acts as a regulator of fertility. Using coculture assays, we demonstrate that osteoblasts are able to induce testosterone production by the testes, though they fail to influence estrogen production by the ovaries. An...

Selection in dairy cattle for a higher milk yield has coincided with declined fertility. One of the factors is reduced expression of estrous behavior. Changes in systems that regulate the estrous behavior could be manifested by altered gene expression. This literature review describes the current knowledge on mechanisms and genes involved in the regulation of estrous behavior. The endocrinologi...