Muscarinic M2 receptor antagonists with high subtype selectivity (M2/M1) will decrease the toxicity in central nervous system in treatment of AD. The exploration of quantitative structure-selectivity relationship (QSSR) to muscarinic M2 receptor antagonists will provide design information for drug with fewer side effects. In this paper, CoMFA models of pK(i)(M1), pK(i)(M2) and p[K(i)(M2)/K(i)(M...

We study the existence of global-in-time weak solutions to a coupled microscopicmacroscopic bead-spring model with microscopic cut-off, which arises from the kinetic theory of dilute solutions of polymeric liquids with noninteracting polymer chains. The model consists of the unsteady incompressible Navier–Stokes equations in a bounded domain Ω ⊂ Rd, d = 2 or 3, for the velocity and the pressure...

We report here the first experimental measurements of nonlinear rheological material properties of hagfish slime, a hydrated biopolymer/biofiber network, and develop a microstructural constitutive model to explain the observed nonlinear viscoelastic behavior. The linear elastic modulus of the network is observed to be G′ ≈ 0.02 Pa for timescales 0.1 s ≤ t ≤ 10 s, making it one of the softest el...

Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice has provided a tractable small animal model for dissecting gammaherpesvirus pathogenesis. The MHV68 latency associated antigen M2 promotes viral latency establishment in germinal center (GC) B cells and plays an important role in virus infection of plasma cells (PCs), which is linked to virus reactivation. More recently,...

The specific activity of ribonucleotide reductase was found to increase significantly after deoxyribonucleic acid inhibition in seven species of bacteria investigated. This group of bacteria includes species with B12-dependent ribonucleotide reductase as well as some with an Escherichia coli-type ribonucleotide reductase.

Prof Jeffrey D Sachs a The goal of universal health coverage is deeply embedded in politics, ethics, and international law. Article 25 of the 1948 Universal Declaration of Human Rights states that everyone has the right to a standard of living adequate for health, including medical care, and the right to security in the event of sickness or disability.1 Motherhood and childhood are to be afford...

A bstract We present a family of new M2-brane solutions in AdS 7 × S 4 that calculate toroidal BPS surface operators the $$ \mathcal{N} N = (2 , 0) theory. These observables are conformally invariant and not subject to anomalies so we able evaluate their finite expectation values at leading order large N . In...