We tested the accuracy of MRI for the precise quantification of the volume of osteonecrosis in 30 hips (stage III). The values were compared with direct anatomical measurements of the femoral heads obtained after total hip replacement. When the area of osteonecrosis was determined visually, and manually outlined on each slice, the accuracy of the measurement of volume was satisfactory, and the ...

Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs in any family member, we recommend genetic analysis and counselling as well as early radiological ...

Hemoglobinopathies are very common in Greece, the incidence of beta-thalassemia trait being 8% and that of sickle cell trait ranging from 1 to 32% in various districts. In Greek populations, sickle cell disease (SCD) is mainly represented by S-beta thalassemia.

Closed reduction and application of a spica cast is a standard treatment in children younger than 18 months. Proper abduction and flexion is crucial during cast application. The surgeon, who usually stands holding the lower limbs, often finds this position cumbersome and difficult to control limb position. During the past 6 years, we have used the lotus (crossed legs) position for the surgeon t...

Combination analysis of three polymorphisms predicts the risk for steroid-induced osteonecrosis of the femoral head Masaaki Kuribayashi1, Mikihiro Fujioka1, Kenji A. Takahashi1, Yuji Arai1, Shigeo Nakajima2, Toshikazu Kubo1 1Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Department of Developmental Medicine (Pediatrics), ...

We report a case of osteonecrosis of the femoral head in a young man who is a carrier of the prothrombin gene mutation. We suggest that an electrical injury to his lower limb may have triggered intravascular thrombosis as a result of this mutation with subsequent osteonecrosis of the femoral head. No case of osteonecrosis of the femoral head secondary to a distant electrical injury has previous...

Department of Anatomy, Medical School, University of Thessaly, Panepistimiou 3 (Biopolis), Larisa 41500, Greece Department of Orthopedics, General Hospital of Karditsa, Karditsa 43100, Greece Department of Radiology, University Hospital of Heraklion, Heraklion 71110, Crete, Greece Department of Orthopaedic Surgery Faculty of Medicine, School of Health Sciences, University of Thessaly, Panepisti...

The use of bisphosphonates in the treatment of avascular necrosis of the femoral head is an encouraging but relatively new option with most published data being derived from small trials with limited follow-up. We present a clinicoradiological analysis of 395 hips with avascular necrosis which were treated with oral alendronate for three years with a mean follow-up of four years (1 to 8). Our r...

The present study presents results from a linkage and mutation screening analysis aiming to identify the causative gene of femoral head necrosis, also known as osteonecrosis of femoral head (ONFH), in a Chinese pedigree. We collected clinical data on the osteonecrosis pedigree, and extracted blood and genomic DNA from the family members. Polymerase chain reaction (PCR) and direct sequencing all...