Male sexual development in the nematode Caenorhabditis elegans requires the genes fem-1, fem-2, and fem-3. The current model of sex determination portrays the FEM proteins as components of a novel signal transduction pathway, but the mechanisms involved in signaling through the pathway are not understood. We report the isolation of fem-2 cDNAs in a yeast two-hybrid screen for clones encoding pr...

Even when we look at stationary objects, involuntarily our eyes perform miniature movements and do not stand perfectly still. Such fixational eye movements (FEM) can be decomposed into at least two components: rapid microsaccades and slow (physiological) drift. Despite the general agreement that microsaccades have a central generating mechanism, the origin of drift is less clear. A direct appro...

This study focuses on the topology optimization of structures using a hybrid of level set method (LSM) incorporating sensitivity analysis and isogeometric analysis (IGA). First, the topology optimization problem is formulated using the LSM based on the shape gradient. The shape gradient easily handles boundary propagation with topological changes. In the LSM, the topological gradient method as ...

In this work a novel method for the analysis with trimmed CAD surfaces is presented. The method involves an additional mapping step and the attraction stems from its simplicity and ease of implementation into existing Finite Element (FEM) or Boundary Element (BEM) software. The method is first verified with classical test examples in structural mechanics. Then two practical applications are pre...

The finite element methods (FEM) are important techniques in engineering for solving partial differential equations, but they depend heavily on element shape quality for stability and good performance. In this paper, we introduce the Adaptive Extended Stencil Finite Element Method (AES-FEM) as a means for overcoming this dependence on element shape quality. Our method replaces the traditional b...

BACKGROUND Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength due to a reduction of bone mass and deterioration of bone microstructure predisposing an individual to an increased risk of fracture. Trabecular bone microstructure analysis and finite element models (FEM) have shown to improve the prediction of bone strength beyond bone mineral density (BMD) me...

We present a system that reconstructs the 3D motion of the left ventricle (LV) for a full cardiac cycle using a deformable model built from tagged MR images. Two sets of cues are drawn from tagged MRI. The intersections of the three tagging planes, and the intersections of the LV boundary and the tagging planes, are interpolated onto the mesh vertices. We implement a deformable model to track t...

Abstract. Numerical investigations of fluid structure interaction between unsteady flow and vibrating liner in a combustion chamber are undertaken. The computational study consist of two approaches. Firstly, a partioned procedure consists of coupling the LES code AVBP for combustion modelling with the FEM code CaluliX for structural dynamic analysis. The CFD code CFX together with the FEM Ansys...

This paper presents an overview on applications of hybrid finite element method (FEM) to heat transfer analysis of skin tissue materials. Recent developments on the hybrid fundamental solution based FEM of heat transfer in skin tissues are described. Formulations for all cases are derived by means of modified variational functional and fundamental solutions. Generation of elemental stiffness eq...

In the context of substrate resistance modeling a combined BEM/FEM method is compared to a 3DFEM method. The combined BEM/FEM method is applicable in substrate modeling problems which involve layout-dependent doping patterns for which a standalone BEM would not be accurate enough and for which a standalone FEM would be too slow. The method captures local couplings within the doping pattern with...