The aims of the study were: to evaluate the anti-oxidant potential of calcium channel blockers felodipine (Fel) and amlodipine (Aml); to estimate their effect on ROS production and on NADPH oxidase (NADPHox) expression and function in human aortic smooth muscle cells (SMCs) stimulated with angiotensin II. Human SMCs were stimulated 24h with 1μM Ang II in the presence or absence of 10 μM drugs. ...

The present work is aimed at the optimization of nanosuspension of felodipine, a poorly water soluble antihypertensive drug using Full factorial Design. A 3 Full factorial design using Design Expert Version 8.0.7.1was employed to study the effect of the independent variables (diffusing drug concentration and stabilizer concentration) on the dependent variables (particle size, percentage of drug...

Candesartan is an effective and widely used antihypertensive medication. The effect of candesartan alone or combined with hydrochlorothiazide and felodipine on the quality of life (QOL) of Finnish hypertensive patients was examined. Antihypertensive treatment was started and conducted according to protocol by candesartan 8 mg once daily and then increased to 16 mg once daily, if needed. Thereaf...

We have recently shown that erythropoietin (EPO)-induced hypertension is unrelated to the rise in hematocrit and is marked by elevated cytosolic [Ca+2] and nitric oxide (NO) resistance. The present study was done to determine the effect of EPO on NO production and endothelial NO synthase (eNOS) expression by endothelial cells. Human coronary artery endothelial cells were cultured to subconfluen...