Background: Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is an Xlinked recessive disorder expressed mostly in males. Prevalence of G6PD deficiency varies in different parts of the world’s according to ethnic variation. The incidence varies among different countries in the world and surveys report rates of less than 1% to 35%. The prevalence of G6PD deficiency in the Arab world has variou...

In order to explore the nature of glucose-6-phosphate dehydrogenase (G6PD) deficiency in one of the coastal provinces of the Caspian Sea (Mazandaran) in Iran, we have analysed the G6PD gene in 74 unrelated G6PD-deficient males (2-6 year children) with a history of Favism, by using PCR and subsequent digestion by appropriate restriction enzymes, looking for the presence of certain known mutation...

the quantitative measurements of gc(p37, c=20); (‘p(p=4o, c=20); lgg(p=67. c= 50);iga(p- 67,c: :50)and 1gm (p=67,(’=50) were carried out on patients with favism and healthy individuals, both school boys, from the caspian sea litlorals. comparison of’ these groups revealed differences, significant for gc (x2 =10.177), lgm(x2 9.6151), lga(x2 9.2821), highly significant for igg (x2=47.1228), and n...

Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract and of a novel patient (2) presenting with severe neonatal jaundice. Red blood cells and leukocytes of the patients in family 1 did not contain an...

A hereditary abnormality of the erythrocytes was described in Negroes sensitive to primaquine (1). A similar or identical defect has been detected in the erythrocytes of a considerable proportion of non-Ashkenazic Jews susceptible to favism and sensitive to various drugs (2-4). The primary defect of these erythrocytes is probably the markedly decreased activity of glucose6-phosphate dehydrogena...

In spite of its positive repercussions on nutrition and environment, faba bean still remains an underutilized crop due to the presence of some undesired compounds. The pyrimidine glycosides vicine and convicine are precursors of the aglycones divicine and isouramil, the main factors of favism, a genetic condition which may lead to severe hemolysis after faba bean ingestion. The reduction of vic...

Fish muscle growth is important for the rapidly developing global aquaculture industry, particularly with respect to production and quality. Changes in muscle fibre size are accomplished by altering the balance between protein synthesis and proteolysis. However, our understanding regarding the effects of different protein sources on fish muscle proteins is still limited. Here we report on the p...