Sphingomyelinase (SMase) hydrolyzes membrane sphingomyelin into ceramide, which increases oxidants in nonmuscle cells. Serum SMase activity is elevated in sepsis and heart failure, conditions where muscle oxidants are increased, maximal muscle force is diminished, and fatigue is accelerated. We tested the hypotheses that exogenous SMase and accumulation of ceramide in muscle increases oxidants ...

Disc wheels intended for normal use on passenger cars have to pass three tests before going into production: the dynamic cornering fatigue test, the dynamic radial fatigue test, and the impact test. This paper describes a probability model for prediction of fatigue failures of aluminum disc wheels, which intends to better link the prediction using simulation results with historical test data. F...

This article focuses on the understanding and discussion of accelerated life test (AL T) procedures applied to reciprocal compressors. AL T procedures were analyzed and classified according to time proportional and proportional hazard models. Many papers were published and extensive research has been done in the area of AL T procedures. However, the fast paced changing world demands for a new g...

The main objective of accelerated life tests in this setting is the recovery of the distribution of the random variable representing lifetime which is difficult to observe at a certain level of a given stress factor. A general model for accelerated life test is proposed that utilizes the inverse problem approach, that is, the variable is observe at different level/s and the transfer function is...

Reliability is one of the main salient assets of modern electronic systems and its improvement is of utmost importance in manufacturingof high-reliability electronic products. The only possible means of improving the operational characteristics of electronic systems and reducing their overall lifecycle costs is improving their reliability. This is possible through designing in reliability at th...

In this paper, the fatigue damage and lifetime of 2D SiC/SiC ceramic-matrix composites (CMCs) under cyclic fatigue loading at 750, 1000, 1100, 1200 and 1300 °C in air and in steam atmosphere have been investigated. The damage evolution versus applied cycles of 2D SiC/SiC composites were analyzed using fatigue hysteresis dissipated energy, fatigue hysteresis modulus, fatigue peak strain and inte...

Fatigue life prediction and evaluation are the key technologies to assure the safety and reliability of automotive rubber components. The objective of this study is to develop the fatigue analysis process for vulcanized rubber components, which is applicable to predict fatigue life at initial product design step. Fatigue life prediction methodology of vulcanized natural rubber was proposed by i...

The purpose of the present paper was to analyze the efficiency of an abbreviated, albeit objective posturographic test as an indicator of fatigue. Posturography was measured in 10 healthy adults (age 18-33 years, male/female 7/3). Baseline posturographic measurements were taken for each subject. Later, a shorter (3-min) posturographic test was administered 12 times during 25 h of sleep deprivat...

Composite structures are gaining importance in the aerospace industry; however, uncertain structural integrity due to fatigue under continuous usage is a big concern. It is arguably possible to detect precursors of failures as damage progresses and can be used to predict impending failures. Prognostic algorithms require large amounts of training data to build damage model for making useful pred...