Increasing evidence demonstrates the dissociation of fat deposition, the inflammatory response, and insulin resistance in the development of obesity-related metabolic diseases. As a regulatory enzyme of glycolysis, inducible 6-phosphofructo-2-kinase (iPFK2, encoded by PFKFB3) protects against diet-induced adipose tissue inflammatory response and systemic insulin resistance independently of adip...

Despite the well-known links between obesity and metabolic diseases, and the increased obesity and metabolic diseases among certain ethnic groups, the mechanisms of these observations remain elusive. Several putative explanations exist for why fat affects metabolic health and how this might vary by ethnicity. One such theory is based on the anatomic location of fat deposition. Current literatur...

Previous studies have suggested that the peptide galanin (GAL) in the hypothalamus is related to the preference of an animal for dietary fat. The present report investigates this relationship further to identify the specific GAL-synthesizing cell groups involved and to characterize their association to circulating glucose or hormones and their possible contribution to body fat deposition. Male ...

Three replications of mouse selection populations for high heat loss (MH), low heat loss (ML), and a nonselected control (MC) were used to estimate the feed energy costs of maintenance and gain and to test whether selection had changed these costs. At 21 and 49 d of age, mice were weighed and subjected to dual x-ray densitometry measurement for prediction of body composition. At 21 d, mice were...

This study was conducted to evaluate the carcass yield, abdominal fat deposition and chemical compositions of thigh and breast muscles of male Arian broilers fed three different lysine levels of 1) high lysine (110% NRC), 2) standard level suggested by National Research Council (NRC) and 3) low lysine (90% NRC) based on two expression ways of amino acid contents of feedstuffs, as total amino ac...

Premature birth in conjunction with extremely low birth weight (<1 kg, ELBW) is associated with insulin resistance and increased cardiometabolic health risk compared to birth at full term with normal birth weight (NBW). However, little is known regarding the biologic mediators of these effects. Abdominal and ectopic lipid accumulation is linked to insulin resistance and metabolic dysfunction, y...

essentially the same picture; an initial depression of the respiratory quotient which was maintained in the case of the free-fed animals but which, in the case of the limit-fed group, rose to the control levels after 50 days of treatment. 5. The results are believed to demonstrate that protein deposition in growth-hormone-treated rats can only take place as a result of an increased emphasis on ...

Mesenteric fat belongs to visceral fat. An increased deposition of mesenteric fat contributes to obesity associated complications such as type 2 diabetes and cardiovascular diseases. We have investigated the therapeutic effects of bardoxolone methyl (BARD) on mesenteric adipose tissue of mice fed a high-fat diet (HFD). Male C57BL/6J mice were administered oral BARD during HFD feeding (HFD/BARD)...

BACKGROUND Excessive non-subcutaneous fat deposition may impair the functions of surrounding tissues and organs through the release of inflammatory cytokines and free fatty acids. OBJECTIVE We examined the cross-sectional association between non-subcutaneous adiposity and calcified coronary plaque, a noninvasive measure of coronary artery disease burden. DESIGN Participants in the Multi-Eth...

Preventing obesity could be done by lowering plasma TAG that inhibits adipogenesis. Oat and mushroom beta-glucans in the diet has been reported to lower plasma lipid; however the data focusing on their effects on TAG and obesity are insufficient. In the present study, lowering plasma triacylglycerol, fat deposition, body weight gain (BWG) in rats fed a high fat diet (HFD) was evaluated. Rats in...