Fasciolosis, caused by Fasciola hepatica and Fasciola gigantica, is a trematode zoonosis of interest in public health and livestock production. Like other helminths, F. hepatica modulates the host immune response by inducing potent polarized Th2 and regulatory T cell immune responses and by downregulating the production of Th1 cytokines. In this work, we show that F. hepatica glycans increase T...

BACKGROUND Fasciola hepatica is a helminth parasite of global importance in livestock, with major economic impact. However information on F. hepatica infections in Irish pasture-based dairy herds is limited. Therefore this study was conducted in order to determine the prevalence, seasonality and management factors associated with F. hepatica. A total of 319 Irish dairy herds were selected for t...

Background—Fascioliasis is a parasitic infection, primarily of the liver but after several weeks the biliary tract may also be aVected, related to the trematode Fasciola hepatica. The trematode is distributed worldwide in herbivores but is unusual in humans. Several outbreaks have been attributed to consumption of contaminated watercress and water. The optimal treatment of fascioliasis, particu...

background: fascioliasis is a chronic hepatic disease and may be resulted from mechani­cal/molecular parasite adhesion to host liver tissue. the aim of this study was to detect surface car­bohydrate and lectin, carbohydrate-binding protein isolation that might be responsible of this molecular binding. methods: the present experimental work was conducted in the department of medical parasitol­og...

Fascioliasis is among important parasitic diseases which limit productivity of ruminants in particular cattle. Fasciola hepatica and Fasciola gigantica are the two liver flukes commonly reported to cause fascioliasis in ruminants. Fasciola hepatica may be acquired by man, but not directly from cattle. A person must ingest the metacercaria in order to become infected. The geographical distributi...

BACKGROUND Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole is the preferred drug since is effective against both juvenile and mature parasites. However, res...

background: the purpose of this comparative study was to detect superoxide dismutase (sod) activities in fasciola hepatica, f. gigantica parasites, infected and healthy liver tissues in order to determine of species effects and liver infection on sods activity level. methods: fasciola spp. parasites and sheep liver tissues (healthy and infected liver tissues), 10 samples for each, were collecte...

BACKGROUND Heavy metals tend to bioaccumulate in living organisms, and their accumulation has been a major concern. As mammals are known to excrete heavy metals via their bile, it seems to be very promising to analyse metal burdens of parasites that infect the biliary tree such as liver flukes of the genus Fasciola. The present study was carried out to evaluate F. hepatica and F. gigantica as b...