BACKGROUND Heterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium falciparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falciparum-specific antibody responses. METHODS We used a protein microarray representing 491 P. falciparum...

To compare the severity of Plasmodium vivax malaria with that of P. falciparum malaria, we conducted a retrospective cross-sectional study of 356 adults hospitalized with malaria (2009-2011) in Pakistan. P. vivax and P. falciparum accounted for 83% and 13% of cases, respectively; 79.9% of patients with severe malaria were infected with P. vivax.

BACKGROUND & OBJECTIVES There is paucity of information on the association between Plasmodium falciparum malaria and some human genetic markers in the Niger Delta region of Nigeria. Hence, a study was undertaken in children to assess the current level of subclinical malaria due to P. falciparum. METHODS Blood groups ABO and Rhesus factor, haemoglobin electrophoretic pattern, G-6-PD deficiency...

Rapid, accurate and affordable methods are needed for the diagnosis of malaria. Reported here is an evaluation of a new immunochromatographic strip, the PATH Falciparum Malaria IC Strip, which is impregnated with an immobilized IgM monoclonal antibody that binds to the HRP-II antigen of Plasmodium falciparum. In contrast to other commercially available kits marketed for the rapid diagnosis of f...

Diagnosis of malaria is a fundamental component case management. Parasitological confirmation before treatment was recommended for endemic countries. Microscopy diagnosis malaria, the gold standard as constraints such as: level expertise, quality equipment and reagents may lead to misdiagnosis. The histidine rich protein 2 (HRP-2) based rapid diagnostic test (RDT) detects Plasmodium falcipa...

BACKGROUND The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level. METHODS Respiratory symptoms and physiological aspects were measured longitudinally in Indonesian adults with uncomplicated vivax (n=50) and falciparum (n=50) malaria. Nor...

BACKGROUND Pregnancy is a known risk factor for malaria which is associated with increased maternal and infant mortality and morbidity in areas of moderate-high malaria transmission intensity where Plasmodium falciparum predominates. The nature and impact of malaria, however, is not well understood in pregnant women residing in areas of low, unstable malaria transmission where P. falciparum and...

BACKGROUND Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum malaria detected at birth. We assessed the association between the number and timing of falciparum and vivax malaria episodes during pregnancy on small-for-gestational-age (SGA) and preterm birth. METHODS We analysed observational data collected from antenatal clinics ...

A 2016 study estimated that over 3 billion people are currently at risk of contracting malaria. Although a wide variety medications available to treat malaria, the parasites have started exhibit resistance many commonly used therapeutics necessitating push for new investigations identify novel drug targets. In this study, nucleic acid-binding Alba superfamily proteins human malaria parasite, Pl...

Malaria is one of the leading causes of acute renal failure in south-east Asia especially India and Vietnam, and Africa1. Plasmodium vivax is the predominant malarial parasite in India accounting for 50.4– 56.4% cases in the last five years2. Falciparum malaria is the more severe variant of malaria in the region commonly associated with renal complications. Renal manifestations described in fal...