BACKGROUND During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial response to Ca(2+), P(i), and pH. METHODS AND RESULTS Isometric force was st...

TiN/SiOx duplex coatings were synthesized on AISI304 stainless steel by plasma immersion ion implantation and deposition (PIIID) followed by radio frequency magnetron sputtering (RFMS). The microstructure and tribocorrosion failure behaviors of the duplex coatings were investigated by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy, rec...

Substantial research has been performed over many years to determine the compressive failure limits of spinal motion segments. However, the majority of studies have not considered the natural alignment of the spine, testing only for pure compression loads. This study tested 27 motion segments, ranging from the T6/T7 to L4/L5 levels, from 13 human cadaveric spines. The segments were oriented in ...

MacFarlane, Niall G., G. Murray Darnley, and Godfrey L. Smith. Cellular basis for contractile dysfunction in the diaphragm from a rabbit infarct model of heart failure. Am J Physiol Cell Physiol 278: C739–C746, 2000.—Abnormal respiratory muscle function is thought to contribute to breathlessness and exercise intolerance in heart failure but little is known about possible alterations in the func...

Techniques for bonding denture teeth to acrylic resin denture base remains empirical, with little consensus from the literature, among clinicians or among dental laboratories. Despite of this great variation, the data available regarding effectiveness of various methods used are sparse. The study was carried out to compare the effect of different surface treatments of ridge lap area of acrylic ...

The force required to initiate cracks in dental amalgam beams was measured and related to the microstructure. The force measured was dependent on age and on the distribution of phases on the tension side of the beam. The Ag-Cu phase is most resistant to failure in Dispersalloy and an experimental alloy.

Adhesion-related failures occurs in microelectromechanical systems (MEMS) when suspended elastic members unexpectedly stick to their substrates. This type of device failure is one of the dominant sources of yield loss in MEMS. This paper reviews the physical mechanisms responsible for the failure from both the theoretical and practical stand point. In general, the failure requires two different...

Long timescale (>1 micros) molecular dynamics simulations of protein folding offer a powerful tool for understanding the atomic-scale interactions that determine a protein's folding pathway and stabilize its native state. Unfortunately, when the simulated protein fails to fold, it is often unclear whether the failure is due to a deficiency in the underlying force fields or simply a lack of suff...

Background—During ischemia, the intracellular calcium and inorganic phosphate (Pi) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial response to Ca, Pi, and pH. Methods and Results—Isometric force was studied in m...

BACKGROUND AND PURPOSE Many studies have shown that a position task is more difficult than a force task although both are performed at a similar net muscle force. Thus, the time to task failure is consistently shown to be briefer during the position task. The contributions of the central nervous system to these two types of fatiguing contractions are not completely understood. The purpose of th...