For a number of years increasing attention has been paid to the evaluation of systolic murmurs (White, 1927; Fahr, 1930; Bass et al., 1933; Shapiro, 1939; White et al., 1942; Baker et al., 1943; Levy et al., 1943; Sodeman, 1944; and Master, 1948). It has been found that they are common in patients without evidence of cardiac disease, and the importance of considering factors other than organic ...

EAELIER electrocardiographic recording procedures utilized the limb leads described by Waller and standardized by Einthoven. In 1913, Einthoven, Fahr, and de Waart made the first vectorial approach to the study of electrocardiographic potentials, using the standard limb leads to estimate the mean direction and magnitude of the electromotive forces produced by the heart in the plane denned by th...

EAELIER electrocardiographic recording procedures utilized the limb leads described by Waller and standardized by Einthoven. In 1913, Einthoven, Fahr, and de Waart made the first vectorial approach to the study of electrocardiographic potentials, using the standard limb leads to estimate the mean direction and magnitude of the electromotive forces produced by the heart in the plane denned by th...

Platelet-derived growth factors (PDGF) bind to two related receptor tyrosine kinases, which are encoded by the PDGFRA and PDGFRB genes. Recently, heterozygous PDGFRB mutations have been described in patients diagnosed with idiopathic basal ganglia calcification (IBGC or Fahr disease), a rare inherited neurological disorder. The goal of the present study was to determine whether these mutations ...

In the course of four years work in a clinic for the investigation and follow up of high blood pressure, the impression has been gained that although hypertension may increase greatly the work of the heart, the heart does not fail unless some additional embarrassment is imposed. Hypotensive drugs have, by reducing the work load of the heart, increased the relative importance of these additional...

The suffix 'osis' signifies 'a diseased condition' and hence nephrosis means a diseased condition of the kidney (Webster'sNew International Dictionary). The term nephrosis was used by Muller (1905) to differentiate what he considered degenerative renal disease from other renal conditions to which the term nephritis was applied. He pointed out that hitherto the word nephrosis had been used to de...

The underlying data demonstrates that fibroblast activation protein (FAP) paves the way for fibrosarcoma cells, which require the proteolysis of the extracellular matrix (ECM) and basement membranes to intravasate from implanted subcutaneous primary tumors into blood vessels, be transported to distant organs where they extravasate from the blood vessels, reattach and proliferate to metastases. ...