نتایج جستجو برای: factor vii
تعداد نتایج: 864410 فیلتر نتایج به سال:
S EDITOR MARIO BALDINI, Providence, R. I. BOOK REVIEW EDITOR STEPHEN H. ROBINSON, Boston, Mass. BLOOD The Journal of Hematology II Fi aicx STOHLMAN, Jn., Editor in Chief, Boston, Mass. ERNST R. JAirFE, Associate Editor New York, N. Y. WILLIAM DA .sI x , Founding Editor EDITORIAL BOARD Jom W. ATHENS, Salt Lake City, Utah MARIO BALDINI, Providence, R. I. ERNEST BEIJTLER, Duarte, Calif. DANE R. Bo...
In a patient with lethal factor VII (FVII) deficiency, 2 homozygous nucleotide substitutions were identified in the F7 gene: a IVS7+2T>G transversion involving the IVS7 donor splice site, followed by a mutation at nucleotide 10588 that would result in a missense variation (Arg224Gln). The mutated splice site, located within the first repeat of a minisatellite, is followed by a variable number o...
UNLABELLED This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with...
Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its activated form, it participates in blood coagulation by activating factor X and/or factor IX in the presence of tissue factor and calcium. Clones coding for factor VII were obtained from two cDNA libraries prepared from poly(A) RNA from human liver and Hep G2 cells. The amino acid sequence deduced from th...
Factor VII is the term used by Koller, Loeliger, and Duckert (1951) for the accelerator complex of prothrombin conversion present in both plasma and serum which is markedly reduced by treatment with drugs of the dicoumarin group. It has been shown by Poller (1954 and 1956a) that there is a significant reduction in the anticoagulant action of heparin on the plasma clotting times of patients with...
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