نتایج جستجو برای: factor forkhead box o1 foxo1

تعداد نتایج: 923682  

2016
Vidya Kandula Ramoji Kosuru Haobo Li Dan Yan Qiqi Zhu Qingquan Lian Ren-shan Ge Zhengyuan Xia Michael G. Irwin

Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understood. Some transcription factors have been suggested to regulate the gene program intricate in the pathogenesis of diabetes prompted cardiac injury. Forkhead box transcription factor 1 is a p...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014
Fei Liu Xiao-Jun Ma Qing-Zhu Wang Yan-Yan Zhao Li-Na Wu Gui-Jun Qin

BACKGROUND Hyperproliferation of glomerular mesangial cells (MCs) is a major pathological characteristic in the early stage of diabetic nephropathy (DN). We have previously confirmed that forkhead transcription factor O1 (FoxO1) was significantly downregulated in both the renal cortex of DN rats and MCs cultured under high-glucose (HG) conditions, but the effects and mechanisms of FoxO1 involve...

Journal: :The Journal of clinical investigation 2017
Mattia Quattrocelli David Y Barefield James L Warner Andy H Vo Michele Hadhazy Judy U Earley Alexis R Demonbreun Elizabeth M McNally

Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions such as Duchenne muscular dystrophy, where their use is associated with prolonged ambulation. The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy. Chronic steroid use usually involves once-daily dosing, althou...

2017
Chenying Zhang Jason Lim Jian Liu Bhaskar Ponugoti Sarah Alsadun Chen Tian Rameen Vafa Dana T. Graves

Wound healing is complex and highly orchestrated. It is well appreciated that leukocytes, particularly macrophages, are essential for inducing the formation of new connective tissue, which requires the generation of signals that stimulate mesenchymal stem cells (MSC), myofibroblasts and fibroblasts. A key role for keratinocytes in this complex process has yet to be established. To this end, we ...

2012
Luís Martins Diana Fernández-Mallo Marta G. Novelle María J. Vázquez Manuel Tena-Sempere Rubén Nogueiras Miguel López Carlos Diéguez

Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (ARC). However, there is a paucity of data about the poss...

Journal: :Acta biochimica et biophysica Sinica 2014
Peiyue Dong Yin Mai Zhenyu Zhang Lin Mi Guofang Wu Guiyan Chu Gongshe Yang Shiduo Sun

Diabetes and many other metabolism syndromes are closely related to obesity. To reveal the underlying mechanism of fat deposition, an increasing number of studies are focusing on the functions of miRNAs during adipocytes development. Previous studies have proved that miR-15a/b play important roles in multiple physiological processes; however, their functions during adipogenesis remain unclear. ...

Journal: :Molecular medicine reports 2015
Feng Gao Wenhui Wang

MicroRNAs (miRNAs) are a conserved class of small, endogenous, non protein-coding RNA molecules that are capable of regulating gene expression at post-transcriptional levels and are involved in diverse cellular processes, including cancer pathogenesis. It has previously been reported that miRNA-96 (miR-96) is overexpressed in human colorectal cancer (CRC). However, the underlying mechanism of m...

2016
Bo-Wen Liu Ying-Fan Zhao Jing-Wen Feng Yang Zhang

Objective: To study alternations in forkhead box, class O1 (FOXO1) protein expression in the periodontal tissue of rats during orthodontic tooth movement (OTM). Methods: A total of 60 Sprague-Dawley (SD) rats were randomly and evenly divided into six groups: an untreated control group and 5 groups treated with applied orthodontic force for 1, 3, 7, 10, and 14 days. The left maxillary first mola...

Journal: :International journal of oncology 2013
Ki-Eun Hwang Do-Sim Park Young-Suk Kim Byoung-Ryun Kim Seong-Nam Park Mi-Kyung Lee Seong-Hoon Park Kwon-Ha Yoon Eun-Taik Jeong Hak-Ryul Kim

The expression levels of Prx1 are frequently elevated in several human cancers, including lung cancer and may confer increased resistance to treatment. In this study, we investigated the role of Prx1 in docetaxel-induced apoptosis in A549 lung cancer cells. To test whether Prx1 knockdown affected the sensitivity of A549 cells to docetaxel treatment, we generated short hairpin RNA (shRNA) constr...

Journal: :International journal of molecular medicine 2014
Shu-Jing Ju Yuyan Zhao Xiaocen Chang Lei Guo

Orexin A and B are multifunctional neuropeptides that are involved in the regulation of food intake, energy metabolism, glucose regulation and wakefulness. They signal through two G-protein‑coupled receptors (GPCR): orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). Previous studies have shown that orexins interact with PI3K/AKT signaling pathways through OX1R-coupling in other cell types, ...

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