OBJECTIVE To assess the performance of diffusion tensor imaging (DTI) for the diagnosis of cervical spondylotic myelopathy (CSM) in patients with deformed spinal cord but otherwise unremarkable conventional magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS A total of 33 patients who underwent MRI of the cervical spine including DTI using two-dimensional single-shot interleaved ...

The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown. Fatty acid (FA) kinase is a two-component enzyme system required for extracellular FA uptake and SaeRS activity. Here, we demonstrate the existence of an intracellular nonesterified FA pool in S. aureus that is elevated ...

BACKGROUND AND PURPOSE Tract-based analysis can be used to investigate required tracts extracted from other fiber tracts. However, the fractional anisotropy (FA) threshold influences tractography analysis. The current study evaluated the influence of the FA threshold in measuring diffusion tensor parameters for tract-based analysis of the uncinate fasciculus in subjects with Alzheimer disease (...

Fanconi anemia (FA) is an autosomal recessive disease with diverse clinical symptoms, life-threatening progressive panmyelopathy, and cellular hypersensitivity to cross-linking agents. Currently, 4 genetic subtypes or complementation groups (FA-A through FA-D) have been distinguished among 7 unrelated FA patients. We report the use of genetically marked FA lymphoblastoid cell lines representing...

BACKGROUND & AIMS The biological role of fatty acids (FA) in the perinatal period is under active investigation. We here describe the application of a simplified microanalytical procedure to compare the FA profile of maternal, umbilical cord and infant whole blood, inclusive of all circulating lipid fractions and cells. METHODS The FA composition has been analyzed with a micromethod in 16 tri...

Fanconi anemia (FA) is a heterogenous genetic disease with a high risk of cancer. The FA proteins are essential for interphase DNA damage repair; however, it is incompletely understood why FA-deficient cells also develop gross aneuploidy, leading to cancer. Here, we systematically evaluated the role of the FA proteins in chromosome segregation through functional RNAi screens and analysis of pri...

The recessive visible rough eye mutant effect of fa( swb), a small deletion at the 5' end of the Notch locus, is suppressed when fa(swb) is coupled to five different closely linked deficiencies distal to salivary band 3C7. In addition, an inversion with a proximal breakpoint between 3C3 and 3C5 similarly suppresses the mutant effect. The data support the position effect interpretation of fa( sw...

The high sensitivity of Fanconi's anemia (FA) cells to drug induced DNA interstrand crosslinks (ICL) such as diepoxybutane (DEB) was used as a part of FA screening in the children with clinical suspicion of FA. The study considered a total of 66 children with the hematological and/or congenital phenotypic symptoms reminiscent of FA. Blood samples from patients with clinical suspicion of FA and ...