(1) Background: Congenital factor (F) VII deficiency is caused by mutations in the F7 gene. Patients with modest differences FVII levels may display large clinical severity. The variant p.A354V-p.P464Hfs associated reduced antigen and activity. aim of study was to investigate manifestation this underlying molecular mechanisms. (2) Methods: Analyses were conducted 37 homozygous patients. recombi...

BACKGROUND The proteins in a family, which perform the similar biological functions, may have very different amino acid composition, but they must share the similar 3D structures, and keep a stable central region. In the conservative structure region similar biological functions are performed by two or three catalytic residues with the collaboration of several functional residues at key positio...

Pancreatic islet beta-cells secrete the hormones insulin, amylin and pancreastatin. To search for further beta-cell hormones, we purified peptides from secretory granules isolated from cultured murine beta TC6-F7 beta-cells. We identified a 34-amino-acid peptide (3948 Da), corresponding to Asp(69)-Leu(102) of the proinsulin-like growth factor II E-peptide, which we have termed 'preptin'. Prepti...

The 'V(d, a) Ti reaction has been studied with 79.4-MeV vector polarized deuterons. Angular distributions of the differential cross section and vector analyzing power have been measured for strongly-populated states up to an excitation energy of 5 MeV. Two-particle —one-hole states of the [(trf7/i) (vf7/i) '] configuration were identified from the characteristic L =6 shapes of the differential ...

We assessed the effects of coagulation factor VII (FVII) gene polymorphisms, lipid-related polymorphisms, and exercise training-induced plasma lipoprotein lipid changes on FVII level changes with exercise training in middle- to older-aged men and women. Forty-six healthy sedentary men and women were stabilized on a low-fat diet and then underwent baseline testing, 6 mo of endurance exercise tra...

Skew Hadamard designs (4n−1, 2n−1, n−1) are associated to order 4n skew Hadamard matrices in the natural way. We study the codes spanned by their incidence matrices A and by I +A and show that they are self-dual after extension (resp. extension and augmentation) over fields of characteristic dividing n. Quadratic Residues codes are obtained in the case of the Paley matrix. Results on the p−rank...

Sugarcane molasses is a rich source of antioxidant materials with peroxyl radical scavenging effects. To explore the potent antioxidant activity of sugarcane molasses against 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced peroxyl radicals, 7 methanolic fractions of sugarcane molasses (F1-F7) were separated via bioassay-guided fractionation and evaluated by oxygen radical absorbanc...

The present study is the development of colon targeted matrix tablets of the drug flurbiprofen, a NSAIDS of the class of Ibuprofen designed to prolonged the release for sustained effect. Different formulation (F1 TO F9) batches were made with the help of different polymers and their different proportions (Guar Gum, Eudragit RL, Eudragit RS ) with the help of Wet granulation techniques. The prep...