We have previously shown in separate studies thatMDM2 knockdown via antisense MDM2 (AS-MDM2) andE2F1 overexpression via adenoviral-mediated E2F1(Ad-E2F1) sensitized prostate cancer cells to radiation.Because E2F1 and MDM2 affect apoptosis through bothcommon and independent pathways, we hypothesizedthat coupling these two treatments would result inincreased killin...