To investigate the possibility that low complement concentrations in the plasma and ascites of patients with severe liver disease could be secondary to complement consumption, complement activation was studied in 32 patients with severe liver disease, 11 of whom had spontaneous bacterial peritonitis (SBP). In patients with SBP, plasma C3 and C4 were significantly lower than in uninfected patien...

Background: Hydrogen/deuterium exchange detected by mass spectrometry (HDX-MS) is an experimental technique that provides valuable information about a protein’s structure and dynamics. Data produced by HDX-MS experiments is often interpreted using a crystal structure of the protein. However, it has been suggested that more accurate interpretations can be derived from conformational ensembles pr...

chemical constituents of the essential oil of flowers of lavandula officinalis chaix. growing in isfahan, iran, were studied by tlc and gas chromatography-mass specrtometery (gc-ms) methods. twelve components which constitute 94.8% of the examined oil were identified. the main constituents were linalool (34.1%), 1,8-cineole (18.5%), borneol (14.5%), camphor (10.2%), terpinen-4-ol (4.5%), linaly...

A vital role for complement in adaptive humoral immunity is now beyond dispute. The crucial interaction is that between B cell and follicular dendritic cell-resident complement receptor 2 (CR2, CD21) and its Ag-associated ligands iC3b and C3dg, where the latter have been deposited as a result of classical pathway activation. Despite the obvious importance of this interaction, the location of a ...

The physiological breakdown of C3 has been studied using monoclonal anti-C3 antibodies, and it has been found that the later stages of this process--the breakdown of C3bi--is more complex than had previously been recognized. C3bi is the reaction product produced from C3b by the action of factor I which, in the presence of factor H, produces a double cleavage in the alpha chain of C3b. It is her...

i n s u p p o r t i n g e n v i r o n m e n t a l s u s t a i n a b i l i t y, m a n a g i n g p r o d u c t r e t u r n s h a s b e c o m e a v e r y i m p o r t a n t a n d c h a l l e n g i n g i s s u e. r e s p o n d i n g t o t h i s t r e n d, r e s e a r c h e r s i n m a n y p a r t s o f t h e w o r l d h a v e c o n d u c t e d n u m e r o u s s t u d i e s i n r e v e r s e l o g i ...

A natural liberalization of Datalog is used in the Distributed Knowledge Authorization Language (DKAL). We show that the expressive power of this liberal Datalog is that of existential fixed-point logic. The exposition is self-contained.

The complement system is known to contribute to demyelination in multiple sclerosis and experimental autoimmune encephalomyelitis. However, there are few data concerning the natural adjuvant effect of C3d on the humoral response when it binds to myelin Ags. This study addresses the effect of C3d binding to the myelin oligodendrocyte glycoprotein (MOG) in the induction of experimental autoimmune...