mirs are 17-25 nucleotide non-coding rnas. these rnas target approximately 80% of protein coding mrnas. mirs control gene expression and altered expression of them affects the development of cancer. mirs can function as tumor suppressor via down-regulation of proto-oncogenes and may function as oncogenes by suppressing tumor suppressors. myeloproliferative neoplasias (formerly known as chronic ...

I at the appropriate distance between the ophthalmoscope and the eye under inspection if greater resolution is desired. The lens must not fluoresce, and all examinations are made in a darkened room. There appear to be a number of interesting possibilities for the ultraviolet ophthalmoscope in medical and biological science, not only for the study of the internal eye structures, but also for the...

BACKGROUND Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloproliferative neoplasms. The aim of this study was to examine the role of the JAK...

format=htm Oct. 22, 1999. Baldwin, A.S., “The NF-kappa B and I kappa B proteins: new discoveries and insights', .../wgetcitjournal=Annu Rev+Immunol&volume=14&page=649&display= abstract&format=h Oct. 29, 1999.format=h Oct. 29, 1999. Barcellos-Hoff, M.H., et al., “Redox-mediated activation of latent transforming growth factor-betal, http://endo.edoc .com/volumes/mend/vol-10.09/1077.html. PEDF-S. ...

Background. Sclerochoroidal calcification is an idiopathic rare benign lesion of the sclera or choroid characterized by histological deposition calcium pyrophosphate. Taking into consideration its similar clinical manifestations with other diseases sclera, most dangerous which are malignant, timely verification diagnosis appointment a further observation period important. The aim. description c...

This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which can be assessed by FISH, and can be used to assist in their diagnosis. We discuss the major morphologic categories in which FISH has come to be used including hi...

book, and he has produced a valuable volume on neoplasms of the skin. Although consideration of malignant conditions occupy the greater part of this volume benign neoplasms also receive their due amount of attention. The book is copiously illustrated by excellent photographs and on the whole is clearly written, but we are sorry to see that the author talks of ' tubercular' skin lesions, when re...

The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the conceptof granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors.Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to ...

nevoid basal cell carcinoma syndrome (nbccs), also known as gorlin syndrome, is a hereditary condition characterized by a wide range of developmental abnormalities and a predisposition to neoplasms . the estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1. main clinical manifestations include multiple basal cell carcinomas (bccs), odontogenic keratocysts o...