Acute Toxicity Studies with Insect Attractants. BEROZA, M., INSCOE, M. N., SCHWARTZ, P. H., JR., KEPLINGER, M. L. AND MASTRI, C. W. (1975). Toxicol. Appl. Pharmacol. 31, 421-429. Eight insect attractants and one inhibitor of a sex attractant were tested for acute oral and aerosol inhalation toxicity in rats, for acute dermal toxicity, eye irritation, and primary skin irritation on rabbits, and ...

A 56-year-old woman complained of recurrent attacks of vertigo. Attacks lasted no longer than a second and could be easily provoked by abrupt eye movements. Vertigo disappeared when the left eye was covered. Symptoms had begun after left-sided cataract surgery resulting in subluxation of the left lens. The characteristic feature of iridodonesis is the tremulousness of the iris with eye movement...

Cosmetic products need to have a proven efficacy combined with comprehensive toxicological assessment. Before the current regulation N°1223/2009, 7th Amendment European Cosmetics Directive has banned animal testing for cosmetic and ingredients in 2004 2009, respectively. An increasing number of alternatives been developed validated safety ingredients. For example, 2D cell culture models derived...

The Branched Chain Saturated Alcohol (BCSA) group of fragrance ingredients was evaluated for safety. In humans, no evidence of skin irritation was found at concentrations of 2-10%. Undiluted, 11 materials evaluated caused moderate to severe eye irritation. As current end product use levels are between 0.001% and 1.7%, eye irritation is not a concern. The materials have no or low sensitizing pot...

The main object of our study was to investigate whether the resazurin metabolism assay is a sensitive surfactant and alcohol toxicity test in isolated pig cornea and to compare this recently developed fluorometric assay with the data collected in the eye irritation reference chemical data bank. Resazurin is a substrate that changes color in response to metabolic activity. Isolated pig corneas w...

The bovine corneal opacity and permeability (BCOP) assay is an alternative method to the in vivo Draize eye test in rabbits for evaluating eye irritation in vitro. Here, we compared the numerical results of the BCOP assay with the corresponding histopathology for three different corneas for each test substance, including commercially available shampoos, make-up removers and cleansing foams that...