Apoptosis is a metazoan process of controlled cell elimination that plays critical roles in embryonic development and adult tissue homeostasis. Apoptosis dysregulation contributes to several important diseases, including cancer. Two distinct yet interconnected signaling pathways control apoptosis by activating a core intracellular machinery of death proteases called caspases. The intrinsic apop...

Neurons are costly for an organism to build and maintain, yet at the same time, there has apparently been strong selective pressure on organisms to incorporate additional functions into their nervous systems. Based on the known properties of dendritic trees and synapses (Koch, 2004), I propose a simple, biologically and evolutionary plausible architecture by which a neurons can be used for mult...

In the present study, a biologically active 4-(trifluoromethyl)phenyl piperazin moiety was linked to a 2,2- dimethyl -2H-benzopyran template to generate (3R,4S)-2,2-dimethyl-6-nitro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl) chroman -3-ol (C110g), and the cellular and molecular mechanisms by which C110g exerts cytotoxic effects on the HeLa human cervical cancer cell line were further inves...

Stochastic modeling to represent intrinsic and extrinsic noise is an important challenge in molecular systems biology. There are numerous ways to model intrinsic noise. One framework for intrinsic noise in gene regulatory networks was recently proposed within the discrete setting. In contrast, extrinsic perturbations were rarely modeled due to the complex mechanisms that contribute to its emerg...

Hemostasis comes from the coordinated activation of platelets and plasma clotting factors to form a platelet fibrin clot. Two processes, primary and secondary hemostasis activation of the clotting cascade id done by collagen for the intrinsic pathway, and the extrinsic pathway is activated by the release of tissue factors from the damaged zone. The two converge ento the common pathway which beg...

Under physiological conditions, the coagulation system is designed to maintain the circulating blood in a fluid state, but act towards restoration of vascular integrity by rapid clot formation after vessel injury. Historically, the coagulation cascade was divided into 2 major systems: the extrinsic and the intrinsic pathway (Figure 1).1 The tissue factor (TF)factor VII/VIIa (FVII/FVIIa) complex...

background: motivation is a driver to health worker performance in most ghanaian hospitals. in view of this, ghana’s ministry of health has rolled out enough motivational policies to accentuate work performance of health workers. objective: the focus of this study was to examine the impact of motivation and identify how intrinsic and extrinsic motivating factors affect the work performance of h...

• Antisense oligonucleotides reduce levels of target hepatic mRNA and protein and decrease clotting activity in rabbits. • Selective depletion of factors XI and XII in rabbits attenuates catheter thrombosis, whereas factor VII depletion does not. Central venous catheter thrombosis can cause venous obstruction and pulmonary embolism. To determine the extent to which catheter thrombosis is trigge...

Colorectal cancer is the third leading cause of cancer-related mortality in the world--the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin co...

Central venous catheter thrombosis can cause venous obstruction and pulmonary embolism. To determine the extent to which catheter thrombosis is triggered by the contact or extrinsic pathway of coagulation, we used antisense oligonucleotides (ASOs) to selectively knock down factor (f)XII, fXI, or high-molecular-weight kininogen (HK), key components of the contact pathway, or fVII, which is essen...