نتایج جستجو برای: extension workers ews

تعداد نتایج: 262547  

Journal: :Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1999
A S Chan S MacNeill P Thorner J Squire M Zielenska

Chromosome translocations found in neoplasms often result in the creation of hybrid genes encoding chimeric proteins. Desmoplastic small round cell tumor (DSRCT) is a recently described aggressive malignancy associated with a unique chromosomal translocation t(11;22)(p13;q12). This translocation has recently been characterized, revealing the rearrangement and fusion of the WT1 gene on chromosom...

2008
M. A. Jafarizadeh

The Gell-Mann λ matrices for Lie algebra su(3) are the natural basis for the Hilbert space of Hermitian operators acting on the states of a three-level system(qutrit). So the construction of EWs for two-qutrit states by using these matrices may be an interesting problem. In this paper, several two-qutrit EWs are constructed based on the Gell-Mann matrices by using the linear programming (LP) me...

Journal: :nephro-urology monthly 0
ivan zokalj department of radiology, county hospital cakovec, cakovec, croatia; department of radiology, county hospital cakovec, cakovec, croatia jasminka igrec department of radiology, county hospital cakovec, cakovec, croatia antonio plesnar department of surgery, division of urology, county hospital cakovec, cakovec, croatia

conclusions pnet/ews should be included in the differential diagnosis of renal tumors in symptomatic young adults. patients with localised pnet/ews treated with a combination of surgery and chemotherapy have an excellent chance of long-term survival, as in the case we have presented. introduction primitive neuroectodermal tumor (pnet)/ewing’s sarcoma (ews) belongs to a family of neoplasms that ...

2011
Cornelia von Levetzow Xiaohua Jiang Ynnez Gwye Gregor von Levetzow Long Hung Aaron Cooper Jessie Hao-Ru Hsu Elizabeth R. Lawlor

Ewing sarcoma family tumors (ESFT) are aggressive bone and soft tissue tumors that express EWS-ETS fusion genes as driver mutations. Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin. For the current study we evaluated the consequences of EWS-FLI1 expression in human embryonic stem cell-derived NCS...

2016
Emily R. Theisen Kathleen I. Pishas Ranajeet S. Saund Stephen L. Lessnick

Ewing sarcoma is an aggressive primary pediatric bone tumor, often diagnosed in adolescents and young adults. A pathognomonic reciprocal chromosomal translocation results in a fusion gene coding for a protein which derives its N-terminus from a FUS/EWS/TAF15 (FET) protein family member, commonly EWS, and C-terminus containing the DNA-binding domain of an ETS transcription factor, commonly FLI1....

2012
Michael J. Monument Kirsten M. Johnson Allie H. Grossmann Joshua D. Schiffman R. Lor Randall Stephen L. Lessnick

Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. Chromosomal translocations are a frequent source of these derangements, producing unique fusion proteins with novel oncogenic properties. EWS/ETS fusions in Ewing sarcoma are a prime example of this, resulting in potent chimeric oncoproteins with novel biological properties and a unique transcript...

2014
Simone Wurster Ulrich Meissen

In recent years, Early Warning Systems (EWS) have proven their value by saving many lives. However, most investments into EWS were motivated directly by experienced disaster events and rarely pro-actively by possible upcoming threats. In order to change that we think that besides ethical and humanitarian reasons also the positive economic effects should be analyzed. EWS also help to protect pro...

Journal: :International journal of cancer 2006
Stefania Benini Monia Zuntini Maria Cristina Manara Pinchas Cohen Giordano Nicoletti Patrizia Nanni Youngman Oh Piero Picci Katia Scotlandi

The IGF/IGF-IR system plays a major role in the pathogenesis and progression of Ewing's sarcoma. In this article, the authors evaluated whether the insulin-like growth factor binding protein-3 (IGFBP-3), a molecule with growth-inhibitory and proapoptotic activities, may be exploited for therapeutic applications in the treatment of Ewing's sarcoma (EWS). Expression of IGFBP-3 was analyzed in a p...

2009
Michelle Kinsey Richard Smith Anita K. Iyer Edward R.B. McCabe Stephen L. Lessnick

Most Ewing's sarcomas harbor chromosomal translocations that encode fusions between EWS and ETS family members. Themost common fusion, EWS/FLI, consists of an EWSR1-derived strong transcriptional activation domain fused, in-frame, to the DNA-binding domain–containing portion of FLI1. EWS/FLI functions as an aberrant transcription factor to regulate genes thatmediate the oncogenicphenotype of Ew...

2018
Yu Tanabe Yoshiyuki Suehara Shinji Kohsaka Takuo Hayashi Keisuke Akaike Kenta Mukaihara Taisei Kurihara Youngji Kim Taketo Okubo Midori Ishii Saiko Kazuno Kazuo Kaneko Tsuyoshi Saito

Ewing's sarcoma (ES) is the second-most frequent pediatric bone tumor. Chromosomal translocation t(11;22)(q24:q12) results in the formation of EWS/FLI1 gene fusion, which is detected in approximately 90% of tumors of the Ewing family. Several transcriptome studies have provided lists of genes associated with EWS/FLI1 expression. However, the protein expression profiles associated with EWS/FLI1 ...

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