OBJECTIVE Although serotonin reuptake inhibitors (SRIs) are approved for the treatment of obsessive-compulsive disorder (OCD), most OCD patients who have received an adequate SRI trial continue to have clinically significant OCD symptoms. The purpose of this study was to examine the effects of augmenting SRIs with exposure and ritual prevention, an established cognitive-behavioral therapy (CBT)...

Exposure to ultraviolet radiation (UVR) can lead to a range of deleterious responses in the skin. An important form of damage is the DNA photolesion cyclobutane pyrimidine dimer (CPD). CPDs can be highly mutagenic if not repaired prior to cell division and can lead to UV-induced immunosuppression, making them potentially carcinogenic. UVR exposure also produces vitamin D, a prehormone. Differen...

Cervicovaginal epithelium plays a critical role in determining the outcome of virus transmission in the female reproductive tract (FRT) by initiating or suppressing transmission-facilitating mucosal immune responses in naïve and SIVmac239Δnef-vaccinated animals, respectively. In this study, we examined the very early responses of cervical epithelium within 24 h after vaginal exposure to SIV in ...

In the present study, the reliability assessment of performance-based optimally seismic designed reinforced concrete (RC) and steel moment frames is investigated. In order to achieve this task, an efficient methodology is proposed by integrating Monte Carlo simulation (MCS) and neural networks (NN). Two NN models including radial basis function (RBF) and back propagation (BP) models are examine...

the effect of repetitive electrical field stimulation and the response of the guinea-pig and rat ileal longitudinal muscle to single pulse stimulations was examined. single pulse field stimulation produced twitch contraction which was inhibited by repetitive field stimulation (10 hz, 40v, 0.5 msec for 5 m). this inhibition was largely, though never completely, reversed by naloxone. contractions...