wilson's disease is a rare but treatable condition with variable clinical presentations. its diagnosis depends on a combination of clinical and laboratory findings. we evaluated the clinical and laboratory findings in children with wilson's disease (wd). twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed wd were evaluated between 1994 and 2003 at imam khomei...

the whole plant, pergularia daemia (family: asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. the diuretic activity of the different extracts at a dose of 400 mg/kg was assessed orally in rats with furosemide as a standard drug using lipschitzs t...

diuretics are the agents which cause increase in excretion of urine. diabetes mellitus (dm) is a multi-factorial disorder characterized by hyperglycemia resulting from an increased hepatic glucose production and diminished insulin secretion. the present study was undertaken to study the diuretic and anti-diabetic activity of esculin. esculin was found to have potent diuretic activity in normal ...

Albumin excretion marks early glomerular injury in hypertension. This study investigated heritability of albumin excretion in twin pairs and its genetic determination by adrenergic pathway polymorphism. Genetic associations used single nucleotide polymorphisms at adrenergic pathway loci spanning catecholamine biosynthesis, storage, catabolism, receptor action, and postreceptor signal transducti...

This study evaluated the effect of feeding silage to pigs on nitrogen (N) utilization and ammonia (NH3) volatilization. In total, 128 Yorkshire × Hampshire (30–110 kg) were fed commercial feed (Control) or mixed with dried, milled in pelleted form (Pellet-S), fresh, chopped (Silage-Ch) intensively treated (Silage-Pr). Silage replaced 20% crude protein (g/kg). Diet affected daily N excretion, wh...

1. Our purpose was to determine why hypouricaemia is more frequently observed than hypouraemia in the syndrome of inappropriate secretion of antidiuretic hormone. We have retrospectively analysed the scores of 35 patients with a chronic form of hyponatraemia related to the syndrome of inappropriate secretion of antidiuretic hormone and studied prospectively six patients. 2. The patients with hi...

Antidiuretic hormone or arginine vasopressin (AVP) increases water reabsorption in the collecting ducts of the kidney. Three decades ago, experimental models have shown that AVP may increase calcium reabsorption in rat kidney. The objective of this study was to assess whether AVP modulates renal calcium excretion in humans. We analyzed calcium, potassium, and sodium fractional excretion in eigh...

Of the nineteen cases of Gramoxone poisoning treated at the Medical Unit, Toa Payoh Hospital, three survived. The clinical data of these survivors is presented. The maximal ingested dose compatible with life in the present series is twenty millilitresof Grammoxonewhile the excretion rate of paraquat in urine in a non -fatal case is 0.92 mg/hr in the first 24 hours. In the follow-up of these sur...

1. Sympathetic nervous system activity, measured by urinary noradrenaline excretion, was determined in a group of untreated hypertensive subjects (n = 35), a reference group (n = 80) and a normotensive group (n = 51), all derived from a random population sample of 50-year-old men. It was compared with casual and resting blood pressure, urinary sodium excretion, urinary cretinine concentration a...