The objective of this study was to determine the influence nonionic surfactants on effectiveness preservatives used in emulsions containing high surfactant content. Mixtures different concentrations were prepared between polyethoxylated (40) hydrogenated castor oil (PHCO) and polyoxyethylene sorbitan monooleate (PSO), with methylparaben, phenoxyethanol, ethylparaben, propylparaben, isobutylpara...

The stimulation of melanogenesis by novel natural products is desirable for cosmetic applications such as skin tanning, anti-greying, and clinical use treating vitiligo leukoderma disorders. Microphthalmia transcription factor (MITF) a central that controls the expression tyrosinase, which key enzyme responsible catalyzing rate-limiting processes melanin production. Tetrahydrocurcuminoids (THCr...

The increasing number of challenging new chemical entities in development coupled with the pressure to reduce R&D and production costs have created the perfect storm in the pharmaceutical industry. Using a science-based approach to excipient selection will allow you to overcome challenges such as poor bioavailability and stability while optimizing the formulation using the manufacturing process...

Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently been described, and we have now tested their ability to release corticosterone in conscious normal rats. All analogs that released GH also stimulated corticosterone release to some degree, though the relative effects on GH and corticosteron...

The study is aimed to assess the compatibility of bilberry leaf powder extract (BLPE) with six excipients selected for sustained-release (SR) tablet formulation. BLPE was obtained addition L-arginine and Myo-inositol as carriers. Thermogravimetric (TG-DTG) analysis Fourier-transform infrared spectroscopy (FTIR), supported by Pearson correlation analysis, were applied detect possible interaction...

• Mathematical model for dissolution of a polydisperse collection binary granules. Full accounts radial variation in drug and porosity distributions. Reduced when initial concentration greatly exceeds solubility. Model single granule size validated against experimental data. Accurate mechanistic vitro models can deliver insight into release behaviour guide formulation development. Drug profiles...

To improve powder flow of a high-dose direct compression formulation (drug content 30%), we compared a two-step operation for mixing glidants with a conventional one-step glidant mixing process. This two-step mixing operation was studied with two kinds of mixtures; an active pharmaceutical ingredient (API)-glidant combination and a direct compression excipient-glidant combination. The two-step ...